1okc

(Difference between revisions)

Revision as of 00:57, 3 May 2008

Image:1okc.gif

Template:STRUCTURE 1okc

STRUCTURE OF MITOCHONDRIAL ADP/ATP CARRIER IN COMPLEX WITH CARBOXYATRACTYLOSIDE

Overview

ATP, the principal energy currency of the cell, fuels most biosynthetic reactions in the cytoplasm by its hydrolysis into ADP and inorganic phosphate. Because resynthesis of ATP occurs in the mitochondrial matrix, ATP is exported into the cytoplasm while ADP is imported into the matrix. The exchange is accomplished by a single protein, the ADP/ATP carrier. Here we have solved the bovine carrier structure at a resolution of 2.2 A by X-ray crystallography in complex with an inhibitor, carboxyatractyloside. Six alpha-helices form a compact transmembrane domain, which, at the surface towards the space between inner and outer mitochondrial membranes, reveals a deep depression. At its bottom, a hexapeptide carrying the signature of nucleotide carriers (RRRMMM) is located. Our structure, together with earlier biochemical results, suggests that transport substrates bind to the bottom of the cavity and that translocation results from a transient transition from a 'pit' to a 'channel' conformation.

About this Structure

1OKC is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside., Pebay-Peyroula E, Dahout-Gonzalez C, Kahn R, Trezeguet V, Lauquin GJ, Brandolin G, Nature. 2003 Nov 6;426(6962):39-44. PMID:14603310 Page seeded by OCA on Sat May 3 03:57:38 2008

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OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1okc"

@@ Line 1: / Line 1: @@
 [[Image:1okc.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1okc |SIZE=350|CAPTION= <scene name='initialview01'>1okc</scene>, resolution 2.20&Aring;
+The line below this paragraph, containing "STRUCTURE_1okc", creates the "Structure Box" on the page.
-|SITE= <scene name='pdbsite=AC1:Pc2+Binding+Site+For+Chain+A'>AC1</scene>
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=CXT:CARBOXYATRACTYLOSIDE'>CXT</scene>, <scene name='pdbligand=LDM:3-LAURYLAMIDO-N,N&#39;-DIMETHYLPROPYLAMINOXYDE'>LDM</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1okc|  PDB=1okc  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1okc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1okc OCA], [http://www.ebi.ac.uk/pdbsum/1okc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1okc RCSB]</span>
-}}
 '''STRUCTURE OF MITOCHONDRIAL ADP/ATP CARRIER IN COMPLEX WITH CARBOXYATRACTYLOSIDE'''
@@ Line 31: / Line 28: @@
 [[Category: Pebay-Peyroula, E.]]
 [[Category: Trezeguet, V.]]
-[[Category: carrier protein]]
+[[Category: Carrier protein]]
-[[Category: membrane protein]]
+[[Category: Membrane protein]]
-[[Category: mitochondrial transporter]]
+[[Category: Mitochondrial transporter]]
-[[Category: nucleotide translocation]]
+[[Category: Nucleotide translocation]]
-[[Category: transport]]
+[[Category: Transport]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 03:57:38 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:46:33 2008''