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6lr6

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Current revision (14:45, 29 November 2023) (edit) (undo)
 
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<StructureSection load='6lr6' size='340' side='right'caption='[[6lr6]], [[Resolution|resolution]] 3.01&Aring;' scene=''>
<StructureSection load='6lr6' size='340' side='right'caption='[[6lr6]], [[Resolution|resolution]] 3.01&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6lr6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LR6 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6LR6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6lr6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LR6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LR6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2H:4-CHLORO-3-AMINOMETHYL-7-[ETHOXY]-3H-BENZO[C][1,2]OXABOROL-1-OL+MODIFIED+ADENOSINE'>A2H</scene>, <scene name='pdbligand=LSS:5-O-(L-LEUCYLSULFAMOYL)ADENOSINE'>LSS</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.009&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LARS, KIAA1352 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2H:4-CHLORO-3-AMINOMETHYL-7-[ETHOXY]-3H-BENZO[C][1,2]OXABOROL-1-OL+MODIFIED+ADENOSINE'>A2H</scene>, <scene name='pdbligand=LSS:5-O-(L-LEUCYLSULFAMOYL)ADENOSINE'>LSS</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leucine--tRNA_ligase Leucine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.4 6.1.1.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lr6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lr6 OCA], [https://pdbe.org/6lr6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lr6 RCSB], [https://www.ebi.ac.uk/pdbsum/6lr6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lr6 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6lr6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lr6 OCA], [http://pdbe.org/6lr6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lr6 RCSB], [http://www.ebi.ac.uk/pdbsum/6lr6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lr6 ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/SYLC_HUMAN SYLC_HUMAN]] Acute infantile liver failure-multisystemic involvement syndrome. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/SYLC_HUMAN SYLC_HUMAN] Acute infantile liver failure-multisystemic involvement syndrome. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SYLC_HUMAN SYLC_HUMAN]] Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs.<ref>PMID:19426743</ref>
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[https://www.uniprot.org/uniprot/SYLC_HUMAN SYLC_HUMAN] Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs.<ref>PMID:19426743</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6lr6" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6lr6" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Leucine--tRNA ligase]]
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[[Category: Cusack S]]
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[[Category: Cusack, S]]
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[[Category: Li H]]
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[[Category: Li, H]]
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[[Category: Li J]]
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[[Category: Li, J]]
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[[Category: Lin JZ]]
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[[Category: Lin, J Z]]
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[[Category: Liu RJ]]
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[[Category: Liu, R J]]
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[[Category: Long T]]
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[[Category: Long, T]]
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[[Category: Palencia A]]
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[[Category: Palencia, A]]
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[[Category: Wang ED]]
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[[Category: Wang, E D]]
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[[Category: Wang MZ]]
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[[Category: Wang, M Z]]
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[[Category: Zhao JH]]
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[[Category: Zhao, J H]]
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[[Category: Aminoacylation]]
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[[Category: Leur]]
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[[Category: Protein translation]]
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[[Category: Rna binding protein]]
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[[Category: Trna]]
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Current revision

The crystal structure of human cytoplasmic LRS

PDB ID 6lr6

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OCA

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