6lu6
From Proteopedia
(Difference between revisions)
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==Crystal structure of BPTF-BRD with ligand DCBPin5-2 bound== | ==Crystal structure of BPTF-BRD with ligand DCBPin5-2 bound== | ||
| - | <StructureSection load='6lu6' size='340' side='right'caption='[[6lu6]]' scene=''> | + | <StructureSection load='6lu6' size='340' side='right'caption='[[6lu6]], [[Resolution|resolution]] 1.97Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LU6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LU6 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6lu6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LU6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LU6 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lu6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lu6 OCA], [https://pdbe.org/6lu6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lu6 RCSB], [https://www.ebi.ac.uk/pdbsum/6lu6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lu6 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.970063Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EUU:6-[1-[3-(dimethylamino)propyl]indol-5-yl]-2-methylsulfonyl-N-propyl-pyrimidin-4-amine'>EUU</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lu6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lu6 OCA], [https://pdbe.org/6lu6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lu6 RCSB], [https://www.ebi.ac.uk/pdbsum/6lu6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lu6 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BPTF_HUMAN BPTF_HUMAN] Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Lin H]] | [[Category: Lin H]] | ||
Current revision
Crystal structure of BPTF-BRD with ligand DCBPin5-2 bound
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Categories: Homo sapiens | Large Structures | Lin H | Lu HB | Lu T | Lu W | Luo C | Wang J
