6lw5

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Current revision (14:58, 29 November 2023) (edit) (undo)
 
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<StructureSection load='6lw5' size='340' side='right'caption='[[6lw5]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='6lw5' size='340' side='right'caption='[[6lw5]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6lw5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LW5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6LW5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6lw5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LW5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LW5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=QXV:'>QXV</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=QXV:D-methioninamide'>QXV</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6lw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lw5 OCA], [http://pdbe.org/6lw5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lw5 RCSB], [http://www.ebi.ac.uk/pdbsum/6lw5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lw5 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lw5 OCA], [https://pdbe.org/6lw5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lw5 RCSB], [https://www.ebi.ac.uk/pdbsum/6lw5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lw5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX]] Electron-transport protein of unknown function.
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[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/FPR2_HUMAN FPR2_HUMAN] Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors (PubMed:1374236). Binding of FMLP to the receptor causes activation of neutrophils (PubMed:1374236). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1374236). The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4) (PubMed:9547339). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation (By similarity).[UniProtKB:O88536]<ref>PMID:1374236</ref> <ref>PMID:9547339</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Escherichia coli]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chen, T]]
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[[Category: Synthetic construct]]
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[[Category: Wang, M]]
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[[Category: Chen T]]
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[[Category: Wu, B]]
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[[Category: Wang M]]
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[[Category: Zhang, H]]
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[[Category: Wu B]]
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[[Category: Zhao, Q]]
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[[Category: Zhang H]]
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[[Category: Zong, X]]
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[[Category: Zhao Q]]
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[[Category: Complex]]
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[[Category: Zong X]]
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[[Category: Formyl peptide receptor]]
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[[Category: G protein-coupled receptor]]
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[[Category: Membrane protein]]
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[[Category: Peptide agonist]]
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Current revision

Crystal structure of the human formyl peptide receptor 2 in complex with WKYMVm

PDB ID 6lw5

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