6lw5
From Proteopedia
(Difference between revisions)
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<StructureSection load='6lw5' size='340' side='right'caption='[[6lw5]], [[Resolution|resolution]] 2.80Å' scene=''> | <StructureSection load='6lw5' size='340' side='right'caption='[[6lw5]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[6lw5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LW5 OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6lw5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LW5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LW5 FirstGlance]. <br> |
- | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> |
- | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=QXV:D-methioninamide'>QXV</scene></td></tr> |
- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lw5 OCA], [https://pdbe.org/6lw5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lw5 RCSB], [https://www.ebi.ac.uk/pdbsum/6lw5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lw5 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
- | [ | + | [https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/FPR2_HUMAN FPR2_HUMAN] Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors (PubMed:1374236). Binding of FMLP to the receptor causes activation of neutrophils (PubMed:1374236). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1374236). The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4) (PubMed:9547339). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation (By similarity).[UniProtKB:O88536]<ref>PMID:1374236</ref> <ref>PMID:9547339</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
+ | [[Category: Escherichia coli]] | ||
+ | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
- | [[Category: Chen | + | [[Category: Synthetic construct]] |
- | [[Category: Wang | + | [[Category: Chen T]] |
- | [[Category: Wu | + | [[Category: Wang M]] |
- | [[Category: Zhang | + | [[Category: Wu B]] |
- | [[Category: Zhao | + | [[Category: Zhang H]] |
- | [[Category: Zong | + | [[Category: Zhao Q]] |
- | + | [[Category: Zong X]] | |
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Current revision
Crystal structure of the human formyl peptide receptor 2 in complex with WKYMVm
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Categories: Escherichia coli | Homo sapiens | Large Structures | Synthetic construct | Chen T | Wang M | Wu B | Zhang H | Zhao Q | Zong X