6m29

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Current revision (15:11, 29 November 2023) (edit) (undo)
 
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<StructureSection load='6m29' size='340' side='right'caption='[[6m29]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='6m29' size='340' side='right'caption='[[6m29]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6m29]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Metja Metja]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M29 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6M29 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6m29]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii_DSM_2661 Methanocaldococcus jannaschii DSM 2661]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M29 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6M29 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cbiX, cfbA, MJ0970 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243232 METJA])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6m29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m29 OCA], [https://pdbe.org/6m29 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6m29 RCSB], [https://www.ebi.ac.uk/pdbsum/6m29 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6m29 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6m29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m29 OCA], [https://pdbe.org/6m29 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6m29 RCSB], [https://www.ebi.ac.uk/pdbsum/6m29 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6m29 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CFBA_METJA CFBA_METJA]] Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin.
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[https://www.uniprot.org/uniprot/CFBA_METJA CFBA_METJA] Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Metja]]
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[[Category: Methanocaldococcus jannaschii DSM 2661]]
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[[Category: Fujishiro, T]]
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[[Category: Fujishiro T]]
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[[Category: Biosynthetic protein]]
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[[Category: Chelatase]]
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Current revision

Sirohydrochlorin nickelochelatase CfbA in complex with Co2+ and formate

PDB ID 6m29

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