1okk

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1okk.gif|left|200px]]
[[Image:1okk.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1okk |SIZE=350|CAPTION= <scene name='initialview01'>1okk</scene>, resolution 2.05&Aring;
+
The line below this paragraph, containing "STRUCTURE_1okk", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=MNA:Ftsy+-+Gtpase+Motif+Iv'>MNA</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=BZP:N1-CARBOXYPIPERAZINE'>BZP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1okk| PDB=1okk | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1okk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1okk OCA], [http://www.ebi.ac.uk/pdbsum/1okk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1okk RCSB]</span>
+
-
}}
+
'''HOMO-HETERODIMERIC COMPLEX OF THE SRP GTPASES'''
'''HOMO-HETERODIMERIC COMPLEX OF THE SRP GTPASES'''
Line 27: Line 24:
[[Category: Focia, P J.]]
[[Category: Focia, P J.]]
[[Category: Freymann, D M.]]
[[Category: Freymann, D M.]]
-
[[Category: ffh]]
+
[[Category: Ffh]]
-
[[Category: ftsy]]
+
[[Category: Ftsy]]
-
[[Category: gtpase]]
+
[[Category: Gtpase]]
-
[[Category: membrane targeting]]
+
[[Category: Membrane targeting]]
-
[[Category: signal sequence recognition]]
+
[[Category: Signal sequence recognition]]
-
[[Category: srp]]
+
[[Category: Srp]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:58:16 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:46:39 2008''
+

Revision as of 00:58, 3 May 2008

Image:1okk.gif

Template:STRUCTURE 1okk

HOMO-HETERODIMERIC COMPLEX OF THE SRP GTPASES


Overview

Two structurally homologous guanosine triphosphatase (GTPase) domains interact directly during signal recognition particle (SRP)-mediated cotranslational targeting of proteins to the membrane. The 2.05 angstrom structure of a complex of the NG GTPase domains of Ffh and FtsY reveals a remarkably symmetric heterodimer sequestering a composite active site that contains two bound nucleotides. The structure explains the coordinate activation of the two GTPases. Conformational changes coupled to formation of their extensive interface may function allosterically to signal formation of the targeting complex to the signal-sequence binding site and the translocon. We propose that the complex represents a molecular "latch" and that its disengagement is regulated by completion of assembly of the GTPase active site.

About this Structure

1OKK is a Protein complex structure of sequences from Thermus aquaticus. Full crystallographic information is available from OCA.

Reference

Heterodimeric GTPase core of the SRP targeting complex., Focia PJ, Shepotinovskaya IV, Seidler JA, Freymann DM, Science. 2004 Jan 16;303(5656):373-7. PMID:14726591 Page seeded by OCA on Sat May 3 03:58:16 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1okk"
Personal tools