6m7a

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Current revision (15:20, 29 November 2023) (edit) (undo)
 
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====
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==Structure of REV7-R124A complexed with SHLD3(28-73)==
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<StructureSection load='6m7a' size='340' side='right'caption='[[6m7a]]' scene=''>
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<StructureSection load='6m7a' size='340' side='right'caption='[[6m7a]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6m7a]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6M7A FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6m7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m7a OCA], [https://pdbe.org/6m7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6m7a RCSB], [https://www.ebi.ac.uk/pdbsum/6m7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6m7a ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6m7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m7a OCA], [https://pdbe.org/6m7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6m7a RCSB], [https://www.ebi.ac.uk/pdbsum/6m7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6m7a ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MD2L2_HUMAN MD2L2_HUMAN] Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation.<ref>PMID:11459825</ref> <ref>PMID:11459826</ref> <ref>PMID:17719540</ref> <ref>PMID:17296730</ref> <ref>PMID:19443654</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Z-disk]]
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[[Category: Huang HD]]
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[[Category: Li Y]]
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[[Category: Ma YZ]]
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[[Category: Wu BX]]

Current revision

Structure of REV7-R124A complexed with SHLD3(28-73)

PDB ID 6m7a

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OCA

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