7bso
From Proteopedia
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==Crystal structure of the human NLRP9 pyrin domain== | ==Crystal structure of the human NLRP9 pyrin domain== | ||
| - | <StructureSection load='7bso' size='340' side='right'caption='[[7bso]]' scene=''> | + | <StructureSection load='7bso' size='340' side='right'caption='[[7bso]], [[Resolution|resolution]] 2.08Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BSO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BSO FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7bso]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BSO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BSO FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bso OCA], [https://pdbe.org/7bso PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bso RCSB], [https://www.ebi.ac.uk/pdbsum/7bso PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bso ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.08Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bso OCA], [https://pdbe.org/7bso PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bso RCSB], [https://www.ebi.ac.uk/pdbsum/7bso PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bso ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NLRP9_HUMAN NLRP9_HUMAN] As the sensor component of the NLRP9 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens, including rotavirus, initiates the formation of the inflammasome polymeric complex, made of NLRP9, PYCARD and CASP1. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and release in the extracellular milieu. The active cytokines stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. NLRP9 inflammasome activation may be initiated by DHX9 interaction with viral double-stranded RNA (dsRNA), preferentially to short dsRNA segments.<ref>PMID:28636595</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Members of the NLR family pyrin domain containing (NLRPs) are pattern recognition receptors that participate in innate immunity. They form inflammasomes, which are platforms for caspase-1 recruitment and activation. The NLRP pyrin domain (PYD) is critical for the assembly of inflammasomes due to its ability to mediate protein interactions. Despite intensive structural studies on inflammasomes with PYDs, the structure of the PYD of NLRP9-the least studied member of the family-remains unknown. Herein, we report the crystal structure of the human NLRP9 PYD at 2.1 A resolution, which reveals a kinked N-terminal loop oriented toward the interior of the helical bundle. Based on our findings, we propose a regulatory role for the kinked N-terminal loop of NLRP9 PYD in inflammasome assembly. | ||
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| + | Crystal structure of the human NLRP9 pyrin domain reveals a bent N-terminal loop that may regulate inflammasome assembly.,Ha HJ, Park HH FEBS Lett. 2020 Aug;594(15):2396-2405. doi: 10.1002/1873-3468.13866. Epub 2020, Jun 28. PMID:32542766<ref>PMID:32542766</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7bso" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Pyrin domain|Pyrin domain]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Ha HJ]] | [[Category: Ha HJ]] | ||
[[Category: Park HH]] | [[Category: Park HH]] | ||
Current revision
Crystal structure of the human NLRP9 pyrin domain
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