7c3k
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Crystal Structure of mIRGB10== | ==Crystal Structure of mIRGB10== | ||
| - | <StructureSection load='7c3k' size='340' side='right'caption='[[7c3k]]' scene=''> | + | <StructureSection load='7c3k' size='340' side='right'caption='[[7c3k]], [[Resolution|resolution]] 2.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7C3K FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7c3k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus_molossinus Mus musculus molossinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7C3K FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c3k OCA], [https://pdbe.org/7c3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c3k RCSB], [https://www.ebi.ac.uk/pdbsum/7c3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c3k ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c3k OCA], [https://pdbe.org/7c3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c3k RCSB], [https://www.ebi.ac.uk/pdbsum/7c3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c3k ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q0GUM3_MOUSE Q0GUM3_MOUSE] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Immunity-related GTPase B10 (IRGB10) belongs to the interferon (IFN)-inducible GTPases, a family of proteins critical to host defense. It is induced by IFNs after pathogen infection, and plays a role in liberating pathogenic ligands for the activation of the inflammasome by directly disrupting the pathogen membrane. Although IRGB10 has been intensively studied owing to its functional importance in the cell-autonomous immune response, the molecular mechanism of IRGB10-mediated microbial membrane disruption is still unclear. In this study, we report the structure of mouse IRGB10. Our structural study showed that IRGB10 bound to GDP forms an inactive head-to-head dimer. Further structural analysis and comparisons indicated that IRGB10 might change its conformation to activate its membrane-binding and disruptive functions. Based on this observation, we propose a model of the working mechanism of IRGB10 during pathogen membrane disruption. | ||
| + | |||
| + | Molecular basis of IRGB10 oligomerization and membrane association for pathogen membrane disruption.,Ha HJ, Chun HL, Lee SY, Jeong JH, Kim YG, Park HH Commun Biol. 2021 Jan 19;4(1):92. doi: 10.1038/s42003-020-01640-7. PMID:33469160<ref>PMID:33469160</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7c3k" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus molossinus]] | ||
[[Category: Ha HJ]] | [[Category: Ha HJ]] | ||
[[Category: Jeong JH]] | [[Category: Jeong JH]] | ||
[[Category: Kim YG]] | [[Category: Kim YG]] | ||
[[Category: Park HH]] | [[Category: Park HH]] | ||
Current revision
Crystal Structure of mIRGB10
| |||||||||||
