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1okx

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[[Image:1okx.gif|left|200px]]
[[Image:1okx.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1okx |SIZE=350|CAPTION= <scene name='initialview01'>1okx</scene>, resolution 2.80&Aring;
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The line below this paragraph, containing "STRUCTURE_1okx", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=SC1:Scyptolin+A+Binding+Site+For+Chain+B'>SC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=1BO:1-BUTANOL'>1BO</scene>, <scene name='pdbligand=CNT:N-METHYL-META-CHLORO-TYROSINE'>CNT</scene>, <scene name='pdbligand=SUJ:(2R,3R)-2-[(3S,6R)-3-AMINO-6-HYDROXY-2-OXOPIPERIDINYL]-3-HYDROXYBUTANOIC+ACID'>SUJ</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1okx| PDB=1okx | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1okx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1okx OCA], [http://www.ebi.ac.uk/pdbsum/1okx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1okx RCSB]</span>
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}}
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'''BINDING STRUCTURE OF ELASTASE INHIBITOR SCYPTOLIN A'''
'''BINDING STRUCTURE OF ELASTASE INHIBITOR SCYPTOLIN A'''
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[[Category: Schulz, G E.]]
[[Category: Schulz, G E.]]
[[Category: Weckesser, J.]]
[[Category: Weckesser, J.]]
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[[Category: elastase]]
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[[Category: Elastase]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: inhibitor]]
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[[Category: Inhibitor]]
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[[Category: protease]]
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[[Category: Protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:59:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:46:48 2008''
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Revision as of 00:59, 3 May 2008

Image:1okx.gif

Template:STRUCTURE 1okx

BINDING STRUCTURE OF ELASTASE INHIBITOR SCYPTOLIN A


Overview

Natural bioactive compounds are of general interest to pharmaceutical research because they may be used as leads in drug development campaigns. Among them, scyptolin A and B from Scytonema hofmanni PCC 7110 are known to inhibit porcine pancreatic elastase, which in turn resembles the attractive drug target neutrophil elastase. The crystal structure of scyptolin A as bound to pancreatic elastase was solved at 2.8 A resolution. The inhibitor occupies the most prominent subsites S1 through S4 of the elastase and prevents a hydrolytic attack by covering the active center with its rigid ring structure. The observed binding structure may help to design potent elastase inhibitors.

About this Structure

1OKX is a Protein complex structure of sequences from Scytonema hofmanni and Sus scrofa. Full crystallographic information is available from OCA.

Reference

Binding structure of elastase inhibitor scyptolin A., Matern U, Schleberger C, Jelakovic S, Weckesser J, Schulz GE, Chem Biol. 2003 Oct;10(10):997-1001. PMID:14583266 Page seeded by OCA on Sat May 3 03:59:01 2008

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