7ccb
From Proteopedia
(Difference between revisions)
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==Crystal structure of the SPRY domain-containing protein 7 (SPRY7)== | ==Crystal structure of the SPRY domain-containing protein 7 (SPRY7)== | ||
| - | <StructureSection load='7ccb' size='340' side='right'caption='[[7ccb]]' scene=''> | + | <StructureSection load='7ccb' size='340' side='right'caption='[[7ccb]], [[Resolution|resolution]] 1.62Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CCB OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[7ccb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CCB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CCB FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.62Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ccb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ccb OCA], [https://pdbe.org/7ccb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ccb RCSB], [https://www.ebi.ac.uk/pdbsum/7ccb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ccb ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SPRY7_HUMAN SPRY7_HUMAN] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The SPRY/B30.2 domain is one of the most abundant protein domains found in eukaryotes. Vast majority of the SPRY domain-containing proteins are multi-domain proteins. The SPRY domain-containing protein 7 (SPRY7, also named C13orf1, and named chronic lymphocytic leukemia deletion region gene 6 protein, CCLD6, encoded by the spryd7 gene) is the smallest SPRY domain protein in human that does not contain other accessory domains. Here we have determined the crystal structure of human SPRY7 at a resolution of 1.62 A and found that SPRY7 has some unique structural features that are not present in other previously reported SRPY domain structures. Overall, SPRY7 may represent an evolutionary early version of the SPRY domain, and subsequent loop insertions and expansions, residue substitutions, as well as domain combinations have rendered the SPRY domain versatile binding specificities and broad biological functions. These results serve as a useful basis for a profound characterization of the molecular interactions of SPRY7. | ||
| + | |||
| + | Crystal structure of the SPRY domain-containing protein 7 reveals unique structural features.,Yang J, Guan X, Zhang D, Zhao P, Guo S, Kuang Z Biochem Biophys Res Commun. 2020 Oct 20;531(3):350-356. doi:, 10.1016/j.bbrc.2020.07.076. Epub 2020 Aug 14. PMID:32800543<ref>PMID:32800543</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7ccb" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Kuang Z]] | [[Category: Kuang Z]] | ||
[[Category: Yang J]] | [[Category: Yang J]] | ||
Current revision
Crystal structure of the SPRY domain-containing protein 7 (SPRY7)
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