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7ceu

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Current revision (16:07, 29 November 2023) (edit) (undo)
 
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<StructureSection load='7ceu' size='340' side='right'caption='[[7ceu]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='7ceu' size='340' side='right'caption='[[7ceu]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7ceu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Campylobacter_pylori Campylobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CEU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CEU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7ceu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori_26695 Helicobacter pylori 26695]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CEU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CEU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7TS:(5-HYDROXY-6-METHYL-4-{[(3-OXO-2,3-DIHYDRO-1,2-OXAZOL-4-YL)AMINO]METHYL}PYRIDIN-3-YL)METHYL+DIHYDROGEN+PHOSPHATE'>7TS</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">iscS, HP_0220 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=85962 Campylobacter pylori])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7TS:(5-HYDROXY-6-METHYL-4-{[(3-OXO-2,3-DIHYDRO-1,2-OXAZOL-4-YL)AMINO]METHYL}PYRIDIN-3-YL)METHYL+DIHYDROGEN+PHOSPHATE'>7TS</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cysteine_desulfurase Cysteine desulfurase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.1.7 2.8.1.7] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ceu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ceu OCA], [https://pdbe.org/7ceu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ceu RCSB], [https://www.ebi.ac.uk/pdbsum/7ceu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ceu ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ceu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ceu OCA], [https://pdbe.org/7ceu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ceu RCSB], [https://www.ebi.ac.uk/pdbsum/7ceu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ceu ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ISCS_HELPY ISCS_HELPY]] Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
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[https://www.uniprot.org/uniprot/ISCS_HELPY ISCS_HELPY] Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7ceu" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7ceu" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Cysteine desulfurase 3D structures|Cysteine desulfurase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Campylobacter pylori]]
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[[Category: Helicobacter pylori 26695]]
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[[Category: Cysteine desulfurase]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Fujishiro, T]]
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[[Category: Fujishiro T]]
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[[Category: Nakamura, R]]
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[[Category: Nakamura R]]
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[[Category: Takahashi, Y]]
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[[Category: Takahashi Y]]
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[[Category: Biosynthetic protein]]
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[[Category: Cycloserine]]
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[[Category: Cysteine metabolism]]
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[[Category: Fe-s cluster biosynthesis]]
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[[Category: Inhibitor]]
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[[Category: Plp-dependent enzyme]]
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Current revision

Crystal structure of L-cycloserine-bound form of cysteine desulfurase NifS from Helicobacter pylori

PDB ID 7ceu

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