7cfz

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Current revision (16:07, 29 November 2023) (edit) (undo)
 
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<StructureSection load='7cfz' size='340' side='right'caption='[[7cfz]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
<StructureSection load='7cfz' size='340' side='right'caption='[[7cfz]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7cfz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CFZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CFZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7cfz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CFZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CFZ FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NOXA1, P51NOX ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cfz OCA], [https://pdbe.org/7cfz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cfz RCSB], [https://www.ebi.ac.uk/pdbsum/7cfz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cfz ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cfz OCA], [https://pdbe.org/7cfz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cfz RCSB], [https://www.ebi.ac.uk/pdbsum/7cfz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cfz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/NOXA1_HUMAN NOXA1_HUMAN]] Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.<ref>PMID:12657628</ref> <ref>PMID:12716910</ref> <ref>PMID:14617635</ref> <ref>PMID:14978110</ref> <ref>PMID:15181005</ref> <ref>PMID:15824103</ref> <ref>PMID:17602954</ref> <ref>PMID:19755710</ref>
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[https://www.uniprot.org/uniprot/NOXA1_HUMAN NOXA1_HUMAN] Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.<ref>PMID:12657628</ref> <ref>PMID:12716910</ref> <ref>PMID:14617635</ref> <ref>PMID:14978110</ref> <ref>PMID:15181005</ref> <ref>PMID:15824103</ref> <ref>PMID:17602954</ref> <ref>PMID:19755710</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Attri, P]]
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[[Category: Attri P]]
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[[Category: Kim, M]]
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[[Category: Kim M]]
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[[Category: Lee, W]]
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[[Category: Lee W]]
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[[Category: Park, J H]]
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[[Category: Park JH]]
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[[Category: Cytosolic protein]]
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[[Category: Nadph oxidase activator 1]]
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[[Category: Noxa1]]
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[[Category: Sh3]]
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Current revision

SH3 domain of NADPH oxidase activator 1

PDB ID 7cfz

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OCA

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