7ctw
From Proteopedia
(Difference between revisions)
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<StructureSection load='7ctw' size='340' side='right'caption='[[7ctw]], [[Resolution|resolution]] 2.51Å' scene=''> | <StructureSection load='7ctw' size='340' side='right'caption='[[7ctw]], [[Resolution|resolution]] 2.51Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[7ctw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[7ctw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CTW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CTW FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GEX:1-(2-methylsulfanylphenyl)piperazine'>GEX</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.51Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GEX:1-(2-methylsulfanylphenyl)piperazine'>GEX</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ctw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ctw OCA], [https://pdbe.org/7ctw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ctw RCSB], [https://www.ebi.ac.uk/pdbsum/7ctw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ctw ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ctw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ctw OCA], [https://pdbe.org/7ctw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ctw RCSB], [https://www.ebi.ac.uk/pdbsum/7ctw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ctw ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/DRTS_PLAFK DRTS_PLAFK] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.[HAMAP-Rule:MF_00008] | |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Plafa]] | ||
| - | [[Category: Vanichtanankul, J]] | ||
| - | [[Category: Vitsupakorn, D]] | ||
| - | [[Category: Anti-folate]] | ||
| - | [[Category: Anti-malarial]] | ||
| - | [[Category: Antibiotic]] | ||
| - | [[Category: Dihydrofolate reductase]] | ||
| - | [[Category: Fragment]] | ||
| - | [[Category: Oxidoreductase]] | ||
[[Category: Plasmodium falciparum]] | [[Category: Plasmodium falciparum]] | ||
| + | [[Category: Vanichtanankul J]] | ||
| + | [[Category: Vitsupakorn D]] | ||
Current revision
Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with fragment 820, NADPH, dUMP
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