1old

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1old.gif|left|200px]]
[[Image:1old.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1old |SIZE=350|CAPTION= <scene name='initialview01'>1old</scene>
+
The line below this paragraph, containing "STRUCTURE_1old", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=ARM:DEOXY-METHYL-ARGININE'>ARM</scene>, <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1old| PDB=1old | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1old FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1old OCA], [http://www.ebi.ac.uk/pdbsum/1old PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1old RCSB]</span>
+
-
}}
+
'''NMR STRUCTURE OF 24-MER DEOXYRIBONUCLEIC ACID, 7 STRUCTURES'''
'''NMR STRUCTURE OF 24-MER DEOXYRIBONUCLEIC ACID, 7 STRUCTURES'''
Line 19: Line 16:
==About this Structure==
==About this Structure==
-
1OLD is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OLD OCA].
+
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OLD OCA].
==Reference==
==Reference==
Encapsulating an amino acid in a DNA fold., Lin CH, Patel DJ, Nat Struct Biol. 1996 Dec;3(12):1046-50. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8946859 8946859]
Encapsulating an amino acid in a DNA fold., Lin CH, Patel DJ, Nat Struct Biol. 1996 Dec;3(12):1046-50. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8946859 8946859]
-
[[Category: Protein complex]]
 
[[Category: Lin, C H.]]
[[Category: Lin, C H.]]
[[Category: Patel, D J.]]
[[Category: Patel, D J.]]
-
[[Category: deoxyribonucleic acid]]
+
[[Category: Deoxyribonucleic acid]]
-
[[Category: dna]]
+
[[Category: Dna]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:59:55 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:46:56 2008''
+

Revision as of 00:59, 3 May 2008

Image:1old.gif

Template:STRUCTURE 1old

NMR STRUCTURE OF 24-MER DEOXYRIBONUCLEIC ACID, 7 STRUCTURES


Overview

Here we present the first solution structure of a ligand-DNA aptamer complex. Our NMR-molecular dynamics structural studies of the interaction between argininamide and a DNA stem-loop complex establishes that the hairpin loop DNA binding site undergoes an adaptive conformational transition on complex formation. The tip of the DNA loop folds down towards the stem and sandwiches the bound argininamide between reversed Hoogsteen A.C and Watson-Crick G.C base pairs. The argininamide is encapsulated within the structured DNA loop and is stabilized by an intricate set of intermolecular hydrogen bonds and stacking interactions. The structure of the complex lays out the molecular principles defining both the architecture of the internal cavity and the recognition elements that could contribute to ligand discrimination.

About this Structure

Full crystallographic information is available from OCA.

Reference

Encapsulating an amino acid in a DNA fold., Lin CH, Patel DJ, Nat Struct Biol. 1996 Dec;3(12):1046-50. PMID:8946859 Page seeded by OCA on Sat May 3 03:59:55 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1old"
Personal tools