7d2v
From Proteopedia
(Difference between revisions)
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<StructureSection load='7d2v' size='340' side='right'caption='[[7d2v]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='7d2v' size='340' side='right'caption='[[7d2v]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[7d2v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[7d2v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D2V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7D2V FirstGlance]. <br> |
- | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=66F:N-{3-[(5R)-3-AMINO-2,5-DIMETHYL-1,1-DIOXIDO-5,6-DIHYDRO-2H-1,2,4-THIADIAZIN-5-YL]-4-FLUOROPHENYL}-5-FLUOROPYRIDINE-2-CARBOXAMIDE'>66F</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> |
- | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=66F:N-{3-[(5R)-3-AMINO-2,5-DIMETHYL-1,1-DIOXIDO-5,6-DIHYDRO-2H-1,2,4-THIADIAZIN-5-YL]-4-FLUOROPHENYL}-5-FLUOROPYRIDINE-2-CARBOXAMIDE'>66F</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr> | |
- | + | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d2v OCA], [https://pdbe.org/7d2v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d2v RCSB], [https://www.ebi.ac.uk/pdbsum/7d2v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d2v ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d2v OCA], [https://pdbe.org/7d2v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d2v RCSB], [https://www.ebi.ac.uk/pdbsum/7d2v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d2v ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
- | + | [https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> | |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 7d2v" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 7d2v" style="background-color:#fffaf0;"></div> | ||
+ | |||
+ | ==See Also== | ||
+ | *[[Beta secretase 3D structures|Beta secretase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
- | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
- | + | [[Category: Ando S]] | |
- | [[Category: Ando | + | [[Category: Asada N]] |
- | [[Category: Asada | + | [[Category: Fuchino K]] |
- | [[Category: Fuchino | + | [[Category: Fujimoto K]] |
- | [[Category: Fujimoto | + | [[Category: Gijsen HJM]] |
- | [[Category: Gijsen | + | [[Category: Ito H]] |
- | [[Category: Ito | + | [[Category: Kanegawa N]] |
- | [[Category: Kanegawa | + | [[Category: Kusakabe KI]] |
- | [[Category: Kusakabe | + | [[Category: Matsuoka E]] |
- | [[Category: Matsuoka | + | [[Category: Moechars D]] |
- | [[Category: Moechars | + | [[Category: Rombouts FJR]] |
- | [[Category: Rombouts | + | [[Category: Suzuki S]] |
- | [[Category: Suzuki | + | [[Category: Tadano G]] |
- | [[Category: Tadano | + | [[Category: Tonomura Y]] |
- | [[Category: Tonomura | + | [[Category: Yamamoto S]] |
- | [[Category: Yamamoto | + | [[Category: Yamamoto T]] |
- | [[Category: Yamamoto | + | [[Category: Yoshida S]] |
- | [[Category: Yoshida | + | |
- | + | ||
- | + |
Revision as of 16:25, 29 November 2023
Crystal Structure of BACE1 in complex with N-{3-[(5R)-3-amino-2,5-dimethyl-1,1-dioxo-5,6-dihydro-2H-1lambda6,2,4-thiadiazin-5-yl]-4-fluorophenyl}-5-fluoropyridine-2-carboxamide
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Categories: Homo sapiens | Large Structures | Ando S | Asada N | Fuchino K | Fujimoto K | Gijsen HJM | Ito H | Kanegawa N | Kusakabe KI | Matsuoka E | Moechars D | Rombouts FJR | Suzuki S | Tadano G | Tonomura Y | Yamamoto S | Yamamoto T | Yoshida S