7d4a

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "7d4a" [edit=sysop:move=sysop])
Current revision (16:26, 29 November 2023) (edit) (undo)
 
Line 1: Line 1:
==The Crystal Structure of human JMJD2A Tudor domain from Biortus==
==The Crystal Structure of human JMJD2A Tudor domain from Biortus==
-
<StructureSection load='7d4a' size='340' side='right'caption='[[7d4a]]' scene=''>
+
<StructureSection load='7d4a' size='340' side='right'caption='[[7d4a]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D4A OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7D4A FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[7d4a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D4A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7D4A FirstGlance]. <br>
-
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7d4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d4a OCA], [http://pdbe.org/7d4a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7d4a RCSB], [http://www.ebi.ac.uk/pdbsum/7d4a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7d4a ProSAT]</span></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.201&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d4a OCA], [https://pdbe.org/7d4a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d4a RCSB], [https://www.ebi.ac.uk/pdbsum/7d4a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d4a ProSAT]</span></td></tr>
</table>
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/KDM4A_HUMAN KDM4A_HUMAN] Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.<ref>PMID:16024779</ref> <ref>PMID:16603238</ref> <ref>PMID:21694756</ref> Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.<ref>PMID:16024779</ref> <ref>PMID:16603238</ref> <ref>PMID:21694756</ref>
 +
 +
==See Also==
 +
*[[Jumonji domain-containing protein 3D structures|Jumonji domain-containing protein 3D structures]]
 +
== References ==
 +
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
 +
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Bao X]]
[[Category: Bao X]]

Current revision

The Crystal Structure of human JMJD2A Tudor domain from Biortus

PDB ID 7d4a

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/7d4a"
Personal tools