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7d5c

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Current revision (16:27, 29 November 2023) (edit) (undo)
 
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<StructureSection load='7d5c' size='340' side='right'caption='[[7d5c]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='7d5c' size='340' side='right'caption='[[7d5c]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7d5c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7D5C FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7d5c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7D5C FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GV6:[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]+(2S,3S)-2-azanyl-3-methyl-pentanoate'>GV6</scene>, <scene name='pdbligand=GVU:(2E,4S,5S,6E,8E)-10-[(2S,3R,6S,8R,9S)-3-butyl-9-methyl-2-[(1E,3E)-3-methyl-5-oxidanyl-5-oxidanylidene-penta-1,3-dienyl]-3-(4-oxidanyl-4-oxidanylidene-butanoyl)oxy-1,7-dioxaspiro[5.5]undecan-8-yl]-4,8-dimethyl-5-oxidanyl-deca-2,6,8-trienoic+acid'>GVU</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.895&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ILS1, YBL076C, YBL0734 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GV6:[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]+(2S,3S)-2-azanyl-3-methyl-pentanoate'>GV6</scene>, <scene name='pdbligand=GVU:(2E,4S,5S,6E,8E)-10-[(2S,3R,6S,8R,9S)-3-butyl-9-methyl-2-[(1E,3E)-3-methyl-5-oxidanyl-5-oxidanylidene-penta-1,3-dienyl]-3-(4-oxidanyl-4-oxidanylidene-butanoyl)oxy-1,7-dioxaspiro[5.5]undecan-8-yl]-4,8-dimethyl-5-oxidanyl-deca-2,6,8-trienoic+acid'>GVU</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Isoleucine--tRNA_ligase Isoleucine--tRNA ligase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.5 6.1.1.5] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d5c OCA], [https://pdbe.org/7d5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d5c RCSB], [https://www.ebi.ac.uk/pdbsum/7d5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d5c ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d5c OCA], [https://pdbe.org/7d5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d5c RCSB], [https://www.ebi.ac.uk/pdbsum/7d5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d5c ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SYIC_YEAST SYIC_YEAST]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Baker's yeast]]
 
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[[Category: Isoleucine--tRNA ligase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chen, B]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Luo, S]]
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[[Category: Chen B]]
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[[Category: Zhou, H]]
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[[Category: Luo S]]
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[[Category: Ligase-inhibitor complex]]
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[[Category: Zhou H]]
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[[Category: Trna synthetase]]
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Current revision

IleRS in complex with a tRNA site inhibitor

PDB ID 7d5c

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OCA

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