This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.


Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


7daz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (16:29, 29 November 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='7daz' size='340' side='right'caption='[[7daz]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
<StructureSection load='7daz' size='340' side='right'caption='[[7daz]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[7daz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DAZ FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[7daz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DAZ FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=H29:6-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)pyridin-3-amine'>H29</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.64&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6kem|6kem]]</div></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=H29:6-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)pyridin-3-amine'>H29</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GstE14, GSTD14-14, nobo, CG4688 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
+
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7daz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7daz OCA], [https://pdbe.org/7daz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7daz RCSB], [https://www.ebi.ac.uk/pdbsum/7daz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7daz ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7daz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7daz OCA], [https://pdbe.org/7daz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7daz RCSB], [https://www.ebi.ac.uk/pdbsum/7daz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7daz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/GSTEE_DROME GSTEE_DROME]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). Essential for ecdysteroid biosynthesis (PubMed:25344753, PubMed:25300303). May be involved in detoxification (PubMed:22082028).<ref>PMID:22082028</ref> <ref>PMID:25300303</ref> <ref>PMID:25344753</ref>
+
[https://www.uniprot.org/uniprot/GSTEE_DROME GSTEE_DROME] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). Essential for ecdysteroid biosynthesis (PubMed:25344753, PubMed:25300303). May be involved in detoxification (PubMed:22082028).<ref>PMID:22082028</ref> <ref>PMID:25300303</ref> <ref>PMID:25344753</ref>
 +
 
 +
==See Also==
 +
*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Drome]]
 
-
[[Category: Glutathione transferase]]
 
-
[[Category: Large Structures]]
 
-
[[Category: Inaba, K]]
 
-
[[Category: Koiwai, K]]
 
-
[[Category: Niwa, R]]
 
-
[[Category: Senda, T]]
 
-
[[Category: Yumoto, F]]
 
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
-
[[Category: Ecdysteroid]]
+
[[Category: Large Structures]]
-
[[Category: Glutathione s-transferase]]
+
[[Category: Inaba K]]
-
[[Category: Gst]]
+
[[Category: Koiwai K]]
-
[[Category: Gste14]]
+
[[Category: Niwa R]]
-
[[Category: Inhibitor]]
+
[[Category: Senda T]]
-
[[Category: Transferase]]
+
[[Category: Yumoto F]]

Current revision

Crystal structure of Drosophila melanogaster Noppera-bo, glutathione S-transferase epsilon 14 (DmGSTE14), in TDP015- and GSH-bound form

PDB ID 7daz

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools