7dea

==Structure of an avian influenza H5 hemagglutinin from the influenza virus A/duck Northern China/22/2017 (H5N6)==

<StructureSection load='7dea' size='340' side='right'caption='[[7dea]], [[Resolution|resolution]] 2.84&Aring;' scene=''>

<table><tr><td colspan='2'>[[7dea]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DEA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DEA FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.84&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dea OCA], [https://pdbe.org/7dea PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dea RCSB], [https://www.ebi.ac.uk/pdbsum/7dea PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dea ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/A0A7S7YCE5_9INFA A0A7S7YCE5_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324]

[[Category: Influenza A virus]]

[[Category: Gao GF]]

[[Category: Zhang W]]