7dhg
From Proteopedia
(Difference between revisions)
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| - | ==== | + | ==Crystal structure of SARS-CoV-2 Orf9b complex with human TOM70== |
| - | <StructureSection load='7dhg' size='340' side='right'caption='[[7dhg]]' scene=''> | + | <StructureSection load='7dhg' size='340' side='right'caption='[[7dhg]], [[Resolution|resolution]] 2.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7dhg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DHG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DHG FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dhg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dhg OCA], [https://pdbe.org/7dhg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dhg RCSB], [https://www.ebi.ac.uk/pdbsum/7dhg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dhg ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dhg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dhg OCA], [https://pdbe.org/7dhg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dhg RCSB], [https://www.ebi.ac.uk/pdbsum/7dhg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dhg ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TOM70_HUMAN TOM70_HUMAN] Acts as receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) (PubMed:12526792). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner (PubMed:12526792, PubMed:35025629). Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection (PubMed:20628368, PubMed:25609812, PubMed:32728199). Upon Sendai virus infection, recruits HSP90AA1:IRF3:BAX in mitochondrion and the complex induces apoptosis (PubMed:25609812).<ref>PMID:12526792</ref> <ref>PMID:20628368</ref> <ref>PMID:25609812</ref> <ref>PMID:32728199</ref> <ref>PMID:35025629</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Severe acute respiratory syndrome coronavirus 2]] |
| + | [[Category: Cui S]] | ||
| + | [[Category: Gao X]] | ||
| + | [[Category: Olieric V]] | ||
| + | [[Category: Qin B]] | ||
| + | [[Category: Wang M]] | ||
| + | [[Category: Zhu K]] | ||
Current revision
Crystal structure of SARS-CoV-2 Orf9b complex with human TOM70
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