7dij
From Proteopedia
(Difference between revisions)
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==Falcilysin in complex with MK-4815== | ==Falcilysin in complex with MK-4815== | ||
| - | <StructureSection load='7dij' size='340' side='right'caption='[[7dij]]' scene=''> | + | <StructureSection load='7dij' size='340' side='right'caption='[[7dij]], [[Resolution|resolution]] 1.90Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DIJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DIJ FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7dij]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DIJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DIJ FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dij OCA], [https://pdbe.org/7dij PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dij RCSB], [https://www.ebi.ac.uk/pdbsum/7dij PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dij ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H8F:2-(aminomethyl)-3,5-ditert-butyl-phenol'>H8F</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dij OCA], [https://pdbe.org/7dij PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dij RCSB], [https://www.ebi.ac.uk/pdbsum/7dij PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dij ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/FCLN_PLAF7 FCLN_PLAF7] In the food vacuole, acts downstream of proteases plasmepsins PMI and PMII and falcipains during the catabolism of host hemoglobin by cleaving peptide fragments of alpha and beta hemoglobin subunits generated by PMI and PMII and falcipains (PubMed:17074076). In the apicoplast, degrades apicoplast transit peptides after their cleavage (PubMed:17074076). Prefers bulky hydrophobic amino acids in the P1' position at both acidic and neutral pH (By similarity). At P2', prefers hydrophobic residues at acidic pH; at neutral pH, these same residues are abundant but prefers Arg (By similarity). At P3', prefers hydrophobic residues, especially Met, at both pH conditions. At P4' and P5', prefers acidic residues at acidic pH, however, at neutral pH, the enzyme is less selective at these positions (By similarity). The optimal site cleavage at acidic pH is YNEHS-|-FFMEE and, at neutral pH, MKRHS-|-FRMRG (By similarity).[UniProtKB:A0A0L7KF24]<ref>PMID:17074076</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Plasmodium falciparum]] | ||
[[Category: El Sahili A]] | [[Category: El Sahili A]] | ||
[[Category: Lescar J]] | [[Category: Lescar J]] | ||
[[Category: Lin JQ]] | [[Category: Lin JQ]] | ||
Revision as of 16:34, 29 November 2023
Falcilysin in complex with MK-4815
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