1om2
From Proteopedia
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'''SOLUTION NMR STRUCTURE OF THE MITOCHONDRIAL PROTEIN IMPORT RECEPTOR TOM20 FROM RAT IN A COMPLEX WITH A PRESEQUENCE PEPTIDE DERIVED FROM RAT ALDEHYDE DEHYDROGENASE (ALDH)''' | '''SOLUTION NMR STRUCTURE OF THE MITOCHONDRIAL PROTEIN IMPORT RECEPTOR TOM20 FROM RAT IN A COMPLEX WITH A PRESEQUENCE PEPTIDE DERIVED FROM RAT ALDEHYDE DEHYDROGENASE (ALDH)''' | ||
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==Reference== | ==Reference== | ||
Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20., Abe Y, Shodai T, Muto T, Mihara K, Torii H, Nishikawa S, Endo T, Kohda D, Cell. 2000 Mar 3;100(5):551-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10721992 10721992] | Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20., Abe Y, Shodai T, Muto T, Mihara K, Torii H, Nishikawa S, Endo T, Kohda D, Cell. 2000 Mar 3;100(5):551-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10721992 10721992] | ||
| - | [[Category: Aldehyde dehydrogenase (NAD(+))]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
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[[Category: Shodai, T.]] | [[Category: Shodai, T.]] | ||
[[Category: Torii, H.]] | [[Category: Torii, H.]] | ||
| - | [[Category: | + | [[Category: Mitochondrial protein import across outer membrane]] |
| - | [[Category: | + | [[Category: Mitochondrial targeting signal]] |
| - | [[Category: | + | [[Category: Presequence peptide]] |
| - | [[Category: | + | [[Category: Receptor for presequence]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:00:52 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 01:00, 3 May 2008
SOLUTION NMR STRUCTURE OF THE MITOCHONDRIAL PROTEIN IMPORT RECEPTOR TOM20 FROM RAT IN A COMPLEX WITH A PRESEQUENCE PEPTIDE DERIVED FROM RAT ALDEHYDE DEHYDROGENASE (ALDH)
Overview
Most mitochondrial proteins are synthesized in the cytosol as precursor proteins with a cleavable N-terminal presequence and are imported into mitochondria. We report here the NMR structure of a general import receptor, rat Tom20, in a complex with a presequence peptide derived from rat aldehyde dehydrogenase. The cytosolic domain of Tom20 forms an all alpha-helical structure with a groove to accommodate the presequence peptide. The bound presequence forms an amphiphilic helical structure with hydrophobic leucines aligned on one side to interact with a hydrophobic patch in the Tom20 groove. Although the positive charges of the presequence are essential for import ability, presequence binding to Tom20 is mediated mainly by hydrophobic rather than ionic interactions.
About this Structure
1OM2 is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20., Abe Y, Shodai T, Muto T, Mihara K, Torii H, Nishikawa S, Endo T, Kohda D, Cell. 2000 Mar 3;100(5):551-60. PMID:10721992 Page seeded by OCA on Sat May 3 04:00:52 2008
