7dud
From Proteopedia
(Difference between revisions)
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==Crystal Structure of erWalK== | ==Crystal Structure of erWalK== | ||
| - | <StructureSection load='7dud' size='340' side='right'caption='[[7dud]]' scene=''> | + | <StructureSection load='7dud' size='340' side='right'caption='[[7dud]], [[Resolution|resolution]] 1.95Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DUD FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7dud]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DUD FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dud OCA], [https://pdbe.org/7dud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dud RCSB], [https://www.ebi.ac.uk/pdbsum/7dud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dud ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dud OCA], [https://pdbe.org/7dud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dud RCSB], [https://www.ebi.ac.uk/pdbsum/7dud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dud ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/WALK_STAA8 WALK_STAA8] Member of the two-component regulatory system WalK/WalR that regulates genes involved in cell wall metabolism, virulence regulation, biofilm production, oxidative stress resistance and antibiotic resistance via direct or indirect regulation of autolysins (PubMed:14762013, PubMed:17827301, PubMed:22825451). Functions as a sensor protein kinase which is autophosphorylated at a histidine residue in the dimerization domain and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of WalR. In turn, WalR binds to the upstream promoter regions of the target genes to positively and negatively regulate their expression (PubMed:14762013, PubMed:22825451).<ref>PMID:14762013</ref> <ref>PMID:17827301</ref> <ref>PMID:22825451</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Staphylococcus aureus]] | ||
[[Category: Huang W]] | [[Category: Huang W]] | ||
Current revision
Crystal Structure of erWalK
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