7dwh
From Proteopedia
(Difference between revisions)
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| - | ==== | + | ==Complex structure of SAM-dependent methyltransferase ribozyme== |
| - | <StructureSection load='7dwh' size='340' side='right'caption='[[7dwh]]' scene=''> | + | <StructureSection load='7dwh' size='340' side='right'caption='[[7dwh]], [[Resolution|resolution]] 3.10Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7dwh]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DWH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DWH FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dwh OCA], [https://pdbe.org/7dwh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dwh RCSB], [https://www.ebi.ac.uk/pdbsum/7dwh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dwh ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dwh OCA], [https://pdbe.org/7dwh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dwh RCSB], [https://www.ebi.ac.uk/pdbsum/7dwh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dwh ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SNRPA_HUMAN SNRPA_HUMAN] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.<ref>PMID:9848648</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Ribozyme 3D structures|Ribozyme 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Synthetic construct]] |
| + | [[Category: Chen DR]] | ||
| + | [[Category: Gao YQ]] | ||
| + | [[Category: Jiang HY]] | ||
| + | [[Category: Murchie A]] | ||
Current revision
Complex structure of SAM-dependent methyltransferase ribozyme
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