7e1p
From Proteopedia
(Difference between revisions)
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==Crystal structure of Sulfurisphaera tokodaii O6-methylguanine methyltransferase C120S variant in complex with O6-methyldeoxyguanosine== | ==Crystal structure of Sulfurisphaera tokodaii O6-methylguanine methyltransferase C120S variant in complex with O6-methyldeoxyguanosine== | ||
| - | <StructureSection load='7e1p' size='340' side='right'caption='[[7e1p]]' scene=''> | + | <StructureSection load='7e1p' size='340' side='right'caption='[[7e1p]], [[Resolution|resolution]] 1.63Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7E1P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7E1P FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7e1p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfurisphaera_tokodaii_str._7 Sulfurisphaera tokodaii str. 7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7E1P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7E1P FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e1p OCA], [https://pdbe.org/7e1p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e1p RCSB], [https://www.ebi.ac.uk/pdbsum/7e1p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e1p ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.63Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=J03:(2~{R},3~{S},5~{R})-5-(2-azanyl-6-methoxy-purin-9-yl)-2-(hydroxymethyl)oxolan-3-ol'>J03</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e1p OCA], [https://pdbe.org/7e1p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e1p RCSB], [https://www.ebi.ac.uk/pdbsum/7e1p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e1p ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/OGT_SULTO OGT_SULTO] Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated (By similarity). | ||
| + | |||
| + | ==See Also== | ||
| + | *[[DNA methyltransferase 3D structures|DNA methyltransferase 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Sulfurisphaera tokodaii str. 7]] | ||
[[Category: Iizuka Y]] | [[Category: Iizuka Y]] | ||
[[Category: Kikuchi M]] | [[Category: Kikuchi M]] | ||
[[Category: Tsunoda M]] | [[Category: Tsunoda M]] | ||
[[Category: Yamauchi T]] | [[Category: Yamauchi T]] | ||
Revision as of 16:44, 29 November 2023
Crystal structure of Sulfurisphaera tokodaii O6-methylguanine methyltransferase C120S variant in complex with O6-methyldeoxyguanosine
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