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7e44

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Current revision (16:46, 29 November 2023) (edit) (undo)
 
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<StructureSection load='7e44' size='340' side='right'caption='[[7e44]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='7e44' size='340' side='right'caption='[[7e44]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7e44]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecobd Ecobd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7E44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7E44 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7e44]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_BL21(DE3) Escherichia coli BL21(DE3)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7E44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7E44 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COD:DEPHOSPHO+COENZYME+A'>COD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">nudC, ECBD_4036, HO396_19860 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=469008 ECOBD])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COD:DEPHOSPHO+COENZYME+A'>COD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/NAD(+)_diphosphatase NAD(+) diphosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.22 3.6.1.22] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e44 OCA], [https://pdbe.org/7e44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e44 RCSB], [https://www.ebi.ac.uk/pdbsum/7e44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e44 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e44 OCA], [https://pdbe.org/7e44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e44 RCSB], [https://www.ebi.ac.uk/pdbsum/7e44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e44 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/A0A140SS78_ECOBD A0A140SS78_ECOBD]] mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some mRNAs and stabilizes RNA against 5'-processing. Has preference for mRNAs with a 5'-end purine. Catalyzes the hydrolysis of a broad range of dinucleotide pyrophosphates.[HAMAP-Rule:MF_00297]
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[https://www.uniprot.org/uniprot/NUDC_ECOLI NUDC_ECOLI]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ecobd]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Guan, Z Y]]
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[[Category: Guan ZY]]
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[[Category: Yin, P]]
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[[Category: Yin P]]
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[[Category: Zhang, D L]]
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[[Category: Zhang DL]]
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[[Category: Zhou, W]]
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[[Category: Zhou W]]
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[[Category: Dpcoa]]
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[[Category: Hydrolase]]
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[[Category: Nudc]]
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Current revision

Crystal structure of NudC complexed with dpCoA

PDB ID 7e44

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OCA

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