7e6r

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Current revision (16:47, 29 November 2023) (edit) (undo)
 
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<StructureSection load='7e6r' size='340' side='right'caption='[[7e6r]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='7e6r' size='340' side='right'caption='[[7e6r]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7e6r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7E6R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7E6R FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7e6r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_coronavirus_NL63 Human coronavirus NL63]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7E6R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7E6R FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e6r OCA], [https://pdbe.org/7e6r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e6r RCSB], [https://www.ebi.ac.uk/pdbsum/7e6r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e6r ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e6r OCA], [https://pdbe.org/7e6r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e6r RCSB], [https://www.ebi.ac.uk/pdbsum/7e6r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e6r ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/R1A_CVHNL R1A_CVHNL]] The papain-like proteinase 1 (PLP1) and papain-like proteinase 2 (PLP2) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. PLP2 also antagonizes innate immune induction of type I interferon by blocking the nuclear translocation of host IRF-3. The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function (By similarity). Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter (By similarity). Nsp9 is a ssRNA-binding protein (By similarity).
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[https://www.uniprot.org/uniprot/R1A_CVHNL R1A_CVHNL] The papain-like proteinase 1 (PLP1) and papain-like proteinase 2 (PLP2) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. PLP2 also antagonizes innate immune induction of type I interferon by blocking the nuclear translocation of host IRF-3. The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function (By similarity). Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter (By similarity). Nsp9 is a ssRNA-binding protein (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human coronavirus NL63]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Gao, H X]]
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[[Category: Gao HX]]
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[[Category: Li, J]]
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[[Category: Li J]]
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[[Category: Zhang, J]]
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[[Category: Zhang J]]
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[[Category: Zhang, Y T]]
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[[Category: Zhang YT]]
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[[Category: Zhong, F L]]
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[[Category: Zhong FL]]
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[[Category: Zhou, X L]]
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[[Category: Zhou XL]]
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[[Category: Hcov-nl63 3c-like protease]]
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[[Category: Viral protein]]
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Current revision

Crystal structure of HCoV-NL63 3C-like protease,pH5.6

PDB ID 7e6r

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