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7eo5

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Current revision (16:57, 29 November 2023) (edit) (undo)
 
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<StructureSection load='7eo5' size='340' side='right'caption='[[7eo5]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='7eo5' size='340' side='right'caption='[[7eo5]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7eo5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EO5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EO5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7eo5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EO5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EO5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BUX:7-chloranyl-2-[(3-chlorophenyl)amino]pyrano[3,4-e][1,3]oxazine-4,5-dione'>BUX</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BUX:7-chloranyl-2-[(3-chlorophenyl)amino]pyrano[3,4-e][1,3]oxazine-4,5-dione'>BUX</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7eo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7eo5 OCA], [https://pdbe.org/7eo5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7eo5 RCSB], [https://www.ebi.ac.uk/pdbsum/7eo5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7eo5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7eo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7eo5 OCA], [https://pdbe.org/7eo5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7eo5 RCSB], [https://www.ebi.ac.uk/pdbsum/7eo5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7eo5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
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[https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7eo5" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7eo5" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arole, A]]
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[[Category: Arole A]]
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[[Category: Ashok, S]]
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[[Category: Ashok S]]
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[[Category: Deshmukh, P]]
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[[Category: Deshmukh P]]
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[[Category: Padmanabhan, B]]
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[[Category: Padmanabhan B]]
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[[Category: B-mercaptoethanol]]
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[[Category: Bet family]]
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[[Category: Brd2]]
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[[Category: Bromodomain]]
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[[Category: Cme]]
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[[Category: Transcription]]
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Current revision

Crystal structure of pyrano 1,3, oxazine derivative in complex with the second bromodomain of BRD2

PDB ID 7eo5

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