This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


7er7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (17:00, 29 November 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='7er7' size='340' side='right'caption='[[7er7]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='7er7' size='340' side='right'caption='[[7er7]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[7er7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ER7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ER7 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[7er7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ER7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ER7 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A80:4-[(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)CARBAMOYL]BENZOIC+ACID'>A80</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A80:4-[(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)CARBAMOYL]BENZOIC+ACID'>A80</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7er7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7er7 OCA], [https://pdbe.org/7er7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7er7 RCSB], [https://www.ebi.ac.uk/pdbsum/7er7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7er7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7er7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7er7 OCA], [https://pdbe.org/7er7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7er7 RCSB], [https://www.ebi.ac.uk/pdbsum/7er7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7er7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/BLVRB_HUMAN BLVRB_HUMAN]] Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.<ref>PMID:10620517</ref>
+
[https://www.uniprot.org/uniprot/BLVRB_HUMAN BLVRB_HUMAN] Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.<ref>PMID:10620517</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 18: Line 19:
</div>
</div>
<div class="pdbe-citations 7er7" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7er7" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Flavin reductase|Flavin reductase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
 +
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Griesinger, C]]
+
[[Category: Griesinger C]]
-
[[Category: Ha, J H]]
+
[[Category: Ha JH]]
-
[[Category: Kim, M]]
+
[[Category: Kim M]]
-
[[Category: Lee, D]]
+
[[Category: Lee D]]
-
[[Category: Ryu, K S]]
+
[[Category: Ryu KS]]
-
[[Category: Biliverdin reductase b]]
+
-
[[Category: Blvrb]]
+
-
[[Category: Inhibitor]]
+
-
[[Category: Nadp]]
+
-
[[Category: Oxidoreductase]]
+
-
[[Category: Platelet]]
+
-
[[Category: Tamibarotene]]
+
-
[[Category: Thrombovytopenia]]
+

Current revision

Crystal structure of hyman Biliverdin IX-beta reductase B with Tamibarotene (A80)

PDB ID 7er7

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/7er7"
Personal tools