7exe

==Crystal structure of mouse 14-3-3zeta in complex with doubly phosphorylated ADAM22 peptide==

<StructureSection load='7exe' size='340' side='right'caption='[[7exe]], [[Resolution|resolution]] 2.75&Aring;' scene=''>

<table><tr><td colspan='2'>[[7exe]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EXE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EXE FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7exe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7exe OCA], [https://pdbe.org/7exe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7exe RCSB], [https://www.ebi.ac.uk/pdbsum/7exe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7exe ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/1433Z_MOUSE 1433Z_MOUSE] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (By similarity). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity).[UniProtKB:O55043][UniProtKB:P63104]

==See Also==

*[[14-3-3 protein 3D structures|14-3-3 protein 3D structures]]

[[Category: Mus musculus]]

[[Category: Yan L]]