7f3i

==Crystal structure of human YBX2 CSD in complex with m5C RNA in space group P212121==

<StructureSection load='7f3i' size='340' side='right'caption='[[7f3i]], [[Resolution|resolution]] 2.25&Aring;' scene=''>

<table><tr><td colspan='2'>[[7f3i]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F3I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F3I FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f3i OCA], [https://pdbe.org/7f3i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f3i RCSB], [https://www.ebi.ac.uk/pdbsum/7f3i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f3i ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/YBOX2_HUMAN YBOX2_HUMAN] Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full-length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay (By similarity).[UniProtKB:Q9Z2C8]

[[Category: Homo sapiens]]

[[Category: Huang Y]]

[[Category: Zhang Y]]