7vce
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[7vce]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VCE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VCE FirstGlance]. <br> | <table><tr><td colspan='2'>[[7vce]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VCE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VCE FirstGlance]. <br> | ||
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vce OCA], [https://pdbe.org/7vce PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vce RCSB], [https://www.ebi.ac.uk/pdbsum/7vce PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vce ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vce OCA], [https://pdbe.org/7vce PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vce RCSB], [https://www.ebi.ac.uk/pdbsum/7vce PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vce ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/IMPA1_HUMAN IMPA1_HUMAN] Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates.<ref>PMID:17068342</ref> | [https://www.uniprot.org/uniprot/IMPA1_HUMAN IMPA1_HUMAN] Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates.<ref>PMID:17068342</ref> | ||
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| + | ==See Also== | ||
| + | *[[Inositol monophosphatase 3D structures|Inositol monophosphatase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
Current revision
Structural studies of human inositol monophosphatase-1 inhibition by ebselen
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Categories: Homo sapiens | Large Structures | Abuhammad A | Churchill GC | Laurieri N | Lowe ED | McDonough MA | Rice A | Singh N
