7vf4
From Proteopedia
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==Crystal structure of Vps75 from Candida albicans== | ==Crystal structure of Vps75 from Candida albicans== | ||
| - | <StructureSection load='7vf4' size='340' side='right'caption='[[7vf4]]' scene=''> | + | <StructureSection load='7vf4' size='340' side='right'caption='[[7vf4]], [[Resolution|resolution]] 3.10Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VF4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VF4 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7vf4]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans_SC5314 Candida albicans SC5314]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VF4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VF4 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vf4 OCA], [https://pdbe.org/7vf4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vf4 RCSB], [https://www.ebi.ac.uk/pdbsum/7vf4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vf4 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vf4 OCA], [https://pdbe.org/7vf4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vf4 RCSB], [https://www.ebi.ac.uk/pdbsum/7vf4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vf4 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A1D8PT39_CANAL A0A1D8PT39_CANAL] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Vps75 is a histone chaperone that interacts with the fungal-specific histone acetyltransferase Rtt109 and stimulates its acetylation activity on histone H3. Here we report the crystal structure of Vps75 of Candida albicans, one of the most common fungal pathogens. CaVps75 exists as a headphone-like dimer that forms a large negatively charged region on its concave side, showing the potential to bind positively charged regions of histones. The distal ends of the concave side of the CaVps75 dimer are positively charged and each has one more alpha helix than yeast Vps75. CaVps75 exhibits ionic strength- and concentration-dependent higher oligomerization in solution. In the crystal, two dimers are bound through electrostatic interactions between charged regions on the concave side of their earmuff domains, and this inter-dimer interaction differs from the currently known inter-dimer interactions of Vps75s. Our results will help to understand the role of Vps75 in C. albicans. | ||
| + | |||
| + | Crystal structure of histone chaperone Vps75 from Candida albicans.,Wang W, Chen X, Yang Z, Chen X, Li C, Wang M Biochem Biophys Res Commun. 2021 Sep 20;578:136-141. doi:, 10.1016/j.bbrc.2021.09.030. PMID:34562653<ref>PMID:34562653</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7vf4" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Candida albicans SC5314]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Chen X]] | [[Category: Chen X]] | ||
Current revision
Crystal structure of Vps75 from Candida albicans
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Categories: Candida albicans SC5314 | Large Structures | Chen X | Li C | Wang M | Wang W | Yang Z
