7vib

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m (Protected "7vib" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 7vib is ON HOLD until Paper Publication
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==Crystal structure of human ACE2 and GX/P2V RBD==
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<StructureSection load='7vib' size='340' side='right'caption='[[7vib]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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Authors: Guo, Y., Cao, W., Jia, N., Wang, W., Yuan, S., Wang, Y.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7vib]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Pangolin_coronavirus Pangolin coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VIB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VIB FirstGlance]. <br>
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Description: Crystal structure of human ACE2 and GX/P2V RBD
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Guo, Y]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vib OCA], [https://pdbe.org/7vib PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vib RCSB], [https://www.ebi.ac.uk/pdbsum/7vib PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vib ProSAT]</span></td></tr>
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[[Category: Wang, W]]
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</table>
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[[Category: Wang, Y]]
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== Function ==
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[[Category: Cao, W]]
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[https://www.uniprot.org/uniprot/ACE2_HUMAN ACE2_HUMAN] Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.<ref>PMID:10969042</ref> <ref>PMID:10924499</ref> <ref>PMID:14647384</ref>
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[[Category: Jia, N]]
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== References ==
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[[Category: Yuan, S]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Pangolin coronavirus]]
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[[Category: Cao W]]
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[[Category: Guo Y]]
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[[Category: Jia N]]
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[[Category: Wang W]]
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[[Category: Wang Y]]
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[[Category: Yuan S]]

Revision as of 17:25, 29 November 2023

Crystal structure of human ACE2 and GX/P2V RBD

PDB ID 7vib

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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