7vou

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7vou]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VOU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VOU FirstGlance]. <br>
<table><tr><td colspan='2'>[[7vou]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VOU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VOU FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vou OCA], [https://pdbe.org/7vou PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vou RCSB], [https://www.ebi.ac.uk/pdbsum/7vou PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vou ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vou OCA], [https://pdbe.org/7vou PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vou RCSB], [https://www.ebi.ac.uk/pdbsum/7vou PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vou ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[https://www.uniprot.org/uniprot/FOXL2_HUMAN FOXL2_HUMAN]] Blepharophimosis-ptosis-epicanthus inversus syndrome plus;Blepharophimosis-ptosis-epicanthus inversus syndrome type 2;Maligant granulosa cell tumor of the ovary;NON RARE IN EUROPE: Primary ovarian failure;Blepharophimosis-ptosis-epicanthus inversus syndrome type 1. The disease is caused by variants affecting the gene represented in this entry. There is a mutational hotspot in the region coding for the poly-Ala domain, since 30% of all mutations in the ORF lead to poly-Ala expansions, resulting mainly in BPES type II. The disease is caused by variants affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/FOXL2_HUMAN FOXL2_HUMAN] Blepharophimosis-ptosis-epicanthus inversus syndrome plus;Blepharophimosis-ptosis-epicanthus inversus syndrome type 2;Maligant granulosa cell tumor of the ovary;NON RARE IN EUROPE: Primary ovarian failure;Blepharophimosis-ptosis-epicanthus inversus syndrome type 1. The disease is caused by variants affecting the gene represented in this entry. There is a mutational hotspot in the region coding for the poly-Ala domain, since 30% of all mutations in the ORF lead to poly-Ala expansions, resulting mainly in BPES type II. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/FOXL2_HUMAN FOXL2_HUMAN]] Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.<ref>PMID:16153597</ref> <ref>PMID:19010791</ref> <ref>PMID:19429596</ref> <ref>PMID:19744555</ref>
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[https://www.uniprot.org/uniprot/FOXL2_HUMAN FOXL2_HUMAN] Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.<ref>PMID:16153597</ref> <ref>PMID:19010791</ref> <ref>PMID:19429596</ref> <ref>PMID:19744555</ref>
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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<div class="pdbe-citations 7vou" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7vou" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[FOX 3D structures|FOX 3D structures]]
== References ==
== References ==
<references/>
<references/>

Current revision

The crystal structure of human forkhead box protein in complex with DNA 1

PDB ID 7vou

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