7wkx
From Proteopedia
(Difference between revisions)
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| - | ==== | + | ==IL-17A in complex with the humanized antibody HB0017== |
| - | <StructureSection load='7wkx' size='340' side='right'caption='[[7wkx]]' scene=''> | + | <StructureSection load='7wkx' size='340' side='right'caption='[[7wkx]], [[Resolution|resolution]] 2.81Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7wkx]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WKX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WKX FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wkx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wkx OCA], [https://pdbe.org/7wkx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wkx RCSB], [https://www.ebi.ac.uk/pdbsum/7wkx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wkx ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.81Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wkx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wkx OCA], [https://pdbe.org/7wkx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wkx RCSB], [https://www.ebi.ac.uk/pdbsum/7wkx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wkx ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/IL17_HUMAN IL17_HUMAN] Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The pro-inflammatory cytokine interleukin-17A (IL-17A) is a key driver of multiple inflammatory and immune disorders. Therapeutic antibodies targeting IL-17A have been proven effective in treating patients with these diseases; however, large variations in clinical outcomes have been observed with different antibodies. In this study, we developed HB0017, a novel monoclonal antibody that targets human IL-17A. HB0017 specifically and strongly bound to human, cynomolgus monkey, and mouse IL-17A at the physiological interface with the IL-17A receptor. In human and monkey cells, HB0017 potently antagonized the functions of IL-17A through competitive binding. HB0017 functioned equivalently to that of clinically approved antibodies in terms of therapeutic efficacy for inflammatory disorders and psoriasis in a mouse model. The results indicate that HB0017 may be an alternative biological therapy for treating patients with inflammation and autoimmune diseases. | ||
| + | |||
| + | Structural and functional insights into a novel pre-clinical-stage antibody targeting IL-17A for treatment of autoimmune diseases.,Xu JG, Jia H, Chen S, Xu J, Zhan Y, Yu H, Wang W, Kang X, Cui X, Feng Y, Chen X, Xu W, Pan X, Wei X, Li H, Wang Y, Xia S, Liu X, Yang L, He Y, Zhu X Int J Biol Macromol. 2022 Mar 31;202:529-538. doi: , 10.1016/j.ijbiomac.2022.01.119. Epub 2022 Jan 20. PMID:35066019<ref>PMID:35066019</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7wkx" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Antibody 3D structures|Antibody 3D structures]] | ||
| + | *[[Interleukin 3D structures|Interleukin 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: He Y]] |
| + | [[Category: Xu J]] | ||
| + | [[Category: Zhu X]] | ||
Revision as of 17:41, 29 November 2023
IL-17A in complex with the humanized antibody HB0017
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Categories: Homo sapiens | Large Structures | He Y | Xu J | Zhu X
