1onq

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[[Image:1onq.jpg|left|200px]]
[[Image:1onq.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1onq |SIZE=350|CAPTION= <scene name='initialview01'>1onq</scene>, resolution 2.15&Aring;
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The line below this paragraph, containing "STRUCTURE_1onq", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SLF:SULFATE-3-D-GALACTOSYL-BETA-1-1-N-STEAROYL-D-SPHINGOSINE'>SLF</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= CD1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1onq| PDB=1onq | SCENE= }}
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|RELATEDENTRY=[[1gzp|1GZP]], [[1gzq|1GZQ]], [[1cd1|1CD1]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1onq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1onq OCA], [http://www.ebi.ac.uk/pdbsum/1onq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1onq RCSB]</span>
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}}
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'''Crystal Structure of CD1a in Complex with a Sulfatide'''
'''Crystal Structure of CD1a in Complex with a Sulfatide'''
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[[Category: Wilson, I A.]]
[[Category: Wilson, I A.]]
[[Category: Zajonc, D M.]]
[[Category: Zajonc, D M.]]
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[[Category: beta sheet platform,]]
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[[Category: Beta sheet platform]]
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[[Category: protein-glycolipid complex]]
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[[Category: Protein-glycolipid complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:04:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:47:53 2008''
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Revision as of 01:04, 3 May 2008

Image:1onq.jpg

Template:STRUCTURE 1onq

Crystal Structure of CD1a in Complex with a Sulfatide


Contents

Overview

CD1 antigens bind a variety of self and foreign lipid and glycolipid antigens for presentation to CD1-restricted T cell receptors (TCRs). Here we report the crystal structure of human CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A. The lipid adopts an S-shaped conformation, with the sphingosine chain completely buried in the A' pocket and the fatty acid chain emerging from the interface of the A' pocket into the more exposed F' pocket. The headgroup is anchored in the A'-F' junction and protrudes into the F' pocket for TCR recognition. Because the A' pocket is narrow with a fixed terminus, it can act as a molecular 'ruler' to select alkyl chains of a particular length.

Disease

Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[109700]

About this Structure

1ONQ is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A., Zajonc DM, Elsliger MA, Teyton L, Wilson IA, Nat Immunol. 2003 Aug;4(8):808-15. Epub 2003 Jun 29. PMID:12833155 Page seeded by OCA on Sat May 3 04:04:37 2008

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OCA

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