7x8j

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Current revision (17:49, 29 November 2023) (edit) (undo)
 
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<StructureSection load='7x8j' size='340' side='right'caption='[[7x8j]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='7x8j' size='340' side='right'caption='[[7x8j]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7x8j]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X8J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7X8J FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7x8j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X8J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7X8J FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.798&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Mannose-1-phosphate_guanylyltransferase Mannose-1-phosphate guanylyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.13 2.7.7.13] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x8j OCA], [https://pdbe.org/7x8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x8j RCSB], [https://www.ebi.ac.uk/pdbsum/7x8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x8j ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x8j OCA], [https://pdbe.org/7x8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x8j RCSB], [https://www.ebi.ac.uk/pdbsum/7x8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x8j ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/GMPP1_ARATH GMPP1_ARATH]] Essential protein during embryogenesis (PubMed:15266054). Catalyzes a reaction of the Smirnoff-Wheeler pathway, the major route to ascorbate biosynthesis in plants. Plays an essential role in plant growth and development and cell-wall architecture. Provides GDP-mannose, used for cell wall carbohydrate biosynthesis, protein N-glycosylation, as well as for the biosynthesis of the antioxidant ascorbate.<ref>PMID:10097187</ref> <ref>PMID:10655235</ref> <ref>PMID:11226227</ref> <ref>PMID:12671089</ref> <ref>PMID:15064386</ref> <ref>PMID:15266054</ref> <ref>PMID:16244149</ref> <ref>PMID:16720601</ref> <ref>PMID:18849295</ref> <ref>PMID:19011088</ref> <ref>PMID:8790441</ref> <ref>PMID:9390448</ref>
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[https://www.uniprot.org/uniprot/GMPP1_ARATH GMPP1_ARATH] Essential protein during embryogenesis (PubMed:15266054). Catalyzes a reaction of the Smirnoff-Wheeler pathway, the major route to ascorbate biosynthesis in plants. Plays an essential role in plant growth and development and cell-wall architecture. Provides GDP-mannose, used for cell wall carbohydrate biosynthesis, protein N-glycosylation, as well as for the biosynthesis of the antioxidant ascorbate.<ref>PMID:10097187</ref> <ref>PMID:10655235</ref> <ref>PMID:11226227</ref> <ref>PMID:12671089</ref> <ref>PMID:15064386</ref> <ref>PMID:15266054</ref> <ref>PMID:16244149</ref> <ref>PMID:16720601</ref> <ref>PMID:18849295</ref> <ref>PMID:19011088</ref> <ref>PMID:8790441</ref> <ref>PMID:9390448</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
 
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[[Category: Mannose-1-phosphate guanylyltransferase]]
 
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[[Category: Liu, L]]
 
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[[Category: Zhang, C]]
 
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[[Category: Zhao, S]]
 
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
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[[Category: Ascorbic acid]]
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[[Category: Large Structures]]
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[[Category: Guanylyltransferase]]
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[[Category: Liu L]]
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[[Category: Nucleotide sugar]]
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[[Category: Zhang C]]
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[[Category: Transferase]]
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[[Category: Zhao S]]

Current revision

Arabidopsis GDP-D-mannose pyrophosphorylase (VTC1) structure (unliganded)

PDB ID 7x8j

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