1jzp
From Proteopedia
(Difference between revisions)
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==Modified Peptide A (D18-A1) of the Rabbit Skeletal Dihydropyridine Receptor== | ==Modified Peptide A (D18-A1) of the Rabbit Skeletal Dihydropyridine Receptor== | ||
| - | <StructureSection load='1jzp' size='340' side='right'caption='[[1jzp | + | <StructureSection load='1jzp' size='340' side='right'caption='[[1jzp]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1jzp]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JZP FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[1jzp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JZP FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jzp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jzp OCA], [https://pdbe.org/1jzp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jzp RCSB], [https://www.ebi.ac.uk/pdbsum/1jzp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jzp ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jzp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jzp OCA], [https://pdbe.org/1jzp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jzp RCSB], [https://www.ebi.ac.uk/pdbsum/1jzp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jzp ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CAC1S_RABIT CAC1S_RABIT] Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Casarotto | + | [[Category: Oryctolagus cuniculus]] |
| - | [[Category: Dulhunty | + | [[Category: Casarotto MG]] |
| - | [[Category: Green | + | [[Category: Dulhunty AF]] |
| - | [[Category: Pace | + | [[Category: Green D]] |
| - | [[Category: Sakowska | + | [[Category: Pace S]] |
| - | + | [[Category: Sakowska M]] | |
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Revision as of 18:45, 29 November 2023
Modified Peptide A (D18-A1) of the Rabbit Skeletal Dihydropyridine Receptor
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