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1m2s

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Current revision (18:49, 29 November 2023) (edit) (undo)
 
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==Solution Structure of A New Potassium Channels Blocker from the Venom of Chinese Scorpion Buthus martensi Karsch==
==Solution Structure of A New Potassium Channels Blocker from the Venom of Chinese Scorpion Buthus martensi Karsch==
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<StructureSection load='1m2s' size='340' side='right'caption='[[1m2s]], [[NMR_Ensembles_of_Models | 25 NMR models]]' scene=''>
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<StructureSection load='1m2s' size='340' side='right'caption='[[1m2s]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1m2s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M2S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M2S FirstGlance]. <br>
<table><tr><td colspan='2'>[[1m2s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M2S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M2S FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1big|1big]], [[2bmt|2bmt]], [[2crd|2crd]], [[1lir|1lir]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m2s OCA], [https://pdbe.org/1m2s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m2s RCSB], [https://www.ebi.ac.uk/pdbsum/1m2s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m2s ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m2s OCA], [https://pdbe.org/1m2s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m2s RCSB], [https://www.ebi.ac.uk/pdbsum/1m2s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m2s ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/KA162_MESMA KA162_MESMA]] Alpha-KTx 16.2: inhibits large conductance calcium-activated potassium channels (KCa1.1/Slo-beta4 KCNMA1/KCNMB4). It appears to block channel activity by a simple bimolecular inhibition process. Shows a fast association rate and a slow dissociation rate of binding on rat brain synaptosome (PubMed:18199674). Significantly inhibits voltage-dependent sodium current and voltage-dependent delayed rectifier potassium currents (PubMed:14632928).<ref>PMID:14632928</ref> <ref>PMID:18199674</ref> Martentoxin-1: significantly inhibits voltage-dependent sodium current (Nav) and voltage-dependent delayed rectifier potassium current.<ref>PMID:14632928</ref>
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[https://www.uniprot.org/uniprot/KA162_MESMA KA162_MESMA] Alpha-KTx 16.2: inhibits large conductance calcium-activated potassium channels (KCa1.1/Slo-beta4 KCNMA1/KCNMB4). It appears to block channel activity by a simple bimolecular inhibition process. Shows a fast association rate and a slow dissociation rate of binding on rat brain synaptosome (PubMed:18199674). Significantly inhibits voltage-dependent sodium current and voltage-dependent delayed rectifier potassium currents (PubMed:14632928).<ref>PMID:14632928</ref> <ref>PMID:18199674</ref> Martentoxin-1: significantly inhibits voltage-dependent sodium current (Nav) and voltage-dependent delayed rectifier potassium current.<ref>PMID:14632928</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Mesobuthus martensii]]
[[Category: Mesobuthus martensii]]
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[[Category: Hu, G]]
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[[Category: Hu G]]
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[[Category: Li, M]]
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[[Category: Li M]]
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[[Category: Wang, Y]]
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[[Category: Wang Y]]
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[[Category: Wu, G]]
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[[Category: Wu G]]
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[[Category: Wu, H]]
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[[Category: Wu H]]
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[[Category: Zhang, N]]
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[[Category: Zhang N]]
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[[Category: Alpha/beta scaffold]]
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[[Category: Toxin]]
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Current revision

Solution Structure of A New Potassium Channels Blocker from the Venom of Chinese Scorpion Buthus martensi Karsch

PDB ID 1m2s

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