2n07
From Proteopedia
(Difference between revisions)
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==Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic alpha-Conotoxin Vc1.1== | ==Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic alpha-Conotoxin Vc1.1== | ||
| - | <StructureSection load='2n07' size='340' side='right'caption='[[2n07 | + | <StructureSection load='2n07' size='340' side='right'caption='[[2n07]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2n07]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N07 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N07 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[2n07]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_victoriae Conus victoriae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N07 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N07 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n07 OCA], [https://pdbe.org/2n07 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n07 RCSB], [https://www.ebi.ac.uk/pdbsum/2n07 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n07 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n07 OCA], [https://pdbe.org/2n07 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n07 RCSB], [https://www.ebi.ac.uk/pdbsum/2n07 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n07 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/CA1A_CONVC CA1A_CONVC] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This synthetic peptide (produced without hydroxyproline, nor 4-carboxyglutamate) is a neuronal nAChR antagonist that acts as a powerful analgesic. It blocks nAChRs composed of alpha-3 or -5/beta-2 (IC(50)=7.2 uM), alpha-3/beta-2 (IC(50)=7.3 uM), alpha-3/beta-4 (IC(50)=4.2 uM), alpha-3 or -5/beta-4 (IC(50)<30 uM), alpha-4/beta-2 (IC(50)<30 uM), alpha-4/beta-4 (IC(50)<30 uM) and alpha/beta/gamma/delta (IC(50)<30 uM) subunits.<ref>PMID:12779345</ref> <ref>PMID:15770155</ref> | |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Conus victoriae]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Adams | + | [[Category: Adams D]] |
| - | [[Category: Akcan | + | [[Category: Akcan M]] |
| - | [[Category: Berecki | + | [[Category: Berecki G]] |
| - | [[Category: Craik | + | [[Category: Craik D]] |
| - | [[Category: Jia | + | [[Category: Jia X]] |
| - | [[Category: Kaas | + | [[Category: Kaas Q]] |
| - | [[Category: Seymour | + | [[Category: Seymour V]] |
| - | [[Category: Yu | + | [[Category: Yu R]] |
| - | + | ||
| - | + | ||
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Revision as of 18:57, 29 November 2023
Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic alpha-Conotoxin Vc1.1
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Categories: Conus victoriae | Large Structures | Adams D | Akcan M | Berecki G | Craik D | Jia X | Kaas Q | Seymour V | Yu R
