2n7q
From Proteopedia
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==Structure of the transmembrane domain of human nicastrin in SDS micelles== | ==Structure of the transmembrane domain of human nicastrin in SDS micelles== | ||
| - | <StructureSection load='2n7q' size='340' side='right'caption='[[2n7q | + | <StructureSection load='2n7q' size='340' side='right'caption='[[2n7q]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2n7q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2n7q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N7Q FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n7q OCA], [https://pdbe.org/2n7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n7q RCSB], [https://www.ebi.ac.uk/pdbsum/2n7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n7q ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n7q OCA], [https://pdbe.org/2n7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n7q RCSB], [https://www.ebi.ac.uk/pdbsum/2n7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n7q ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | + | [https://www.uniprot.org/uniprot/NICA_HUMAN NICA_HUMAN] Hidradenitis suppurativa. The disease is caused by mutations affecting the gene represented in this entry. | |
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/NICA_HUMAN NICA_HUMAN] Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. | |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Kang | + | [[Category: Kang C]] |
| - | [[Category: Li | + | [[Category: Li Q]] |
| - | [[Category: Li | + | [[Category: Li Y]] |
| - | [[Category: Liew | + | [[Category: Liew L]] |
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Revision as of 18:57, 29 November 2023
Structure of the transmembrane domain of human nicastrin in SDS micelles
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Categories: Homo sapiens | Large Structures | Kang C | Li Q | Li Y | Liew L
