1pyn

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Revision as of 16:42, 12 November 2007

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spinqualitylabelsall models 1pyn, resolution 2.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

DUAL-SITE POTENT, SELECTIVE PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR USING A LINKED FRAGMENT STRATEGY AND A MALONATE HEAD ON THE FIRST SITE

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

A salicylate second site binder was linked to three classes of, phosphotyrosine mimetics to produce potent protein tyrosine phosphatase 1B, (PTP1B) inhibitors which exhibit significant selectivity against other, phosphatases including the most homologous member, TCPTP.

Disease

Known diseases associated with this structure: Abdominal body fat distribution, modifier of OMIM:[176885], Insulin resistance, susceptibility to OMIM:[176885]

About this Structure

1PYN is a Single protein structure of sequence from Homo sapiens with 941 as ligand. Active as Protein-tyrosine-phosphatase, with EC number 3.1.3.48 Full crystallographic information is available from OCA.

Reference

Discovery and SAR of novel, potent and selective protein tyrosine phosphatase 1B inhibitors., Pei Z, Li X, Liu G, Abad-Zapatero C, Lubben T, Zhang T, Ballaron SJ, Hutchins CW, Trevillyan JM, Jirousek MR, Bioorg Med Chem Lett. 2003 Oct 6;13(19):3129-32. PMID:12951078

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