Aciclovir

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Aciclovir (ACV), also known as acyclovir,<ref name="a3">Kevin ES. [https://deutschemedz.de/aciclovir "The Aciclovir"] (in German). Kevin. Retrieved 25 May 2017.</ref> is an antiviral medication.<ref name="a4">de Clercq E, Field HJ (5 October 2005). "Antiviral prodrugs – the development of successful prodrug strategies for antiviral chemotherapy". [https://en.wikipedia.org/wiki/British_Journal_of_Pharmacology British Journal of Pharmacology.] Vol. 147, no. 1. Wiley-Blackwell (published January 2006). pp. 1–11.</ref> It is primarily used for the treatment of herpes simplex virus infections, chickenpox, and shingles.<ref name="a5">[https://www.drugs.com/monograph/acyclovir.html "Acyclovir".] The American Society of Health-System Pharmacists. Archived from the original on 2015-01-05. Retrieved Jan 1, 2015.</ref> Other uses include prevention of cytomegalovirus infections following transplant and severe complications of Epstein–Barr virus infection.<ref name="a5">[https://www.drugs.com/monograph/acyclovir.html "Acyclovir".] The American Society of Health-System Pharmacists. Archived from the original on 2015-01-05. Retrieved Jan 1, 2015.</ref><ref name="a6">PMID:20739216</ref> See also [https://en.wikipedia.org/wiki/Aciclovir Aciclovir].
Aciclovir (ACV), also known as acyclovir,<ref name="a3">Kevin ES. [https://deutschemedz.de/aciclovir "The Aciclovir"] (in German). Kevin. Retrieved 25 May 2017.</ref> is an antiviral medication.<ref name="a4">de Clercq E, Field HJ (5 October 2005). "Antiviral prodrugs – the development of successful prodrug strategies for antiviral chemotherapy". [https://en.wikipedia.org/wiki/British_Journal_of_Pharmacology British Journal of Pharmacology.] Vol. 147, no. 1. Wiley-Blackwell (published January 2006). pp. 1–11.</ref> It is primarily used for the treatment of herpes simplex virus infections, chickenpox, and shingles.<ref name="a5">[https://www.drugs.com/monograph/acyclovir.html "Acyclovir".] The American Society of Health-System Pharmacists. Archived from the original on 2015-01-05. Retrieved Jan 1, 2015.</ref> Other uses include prevention of cytomegalovirus infections following transplant and severe complications of Epstein–Barr virus infection.<ref name="a5">[https://www.drugs.com/monograph/acyclovir.html "Acyclovir".] The American Society of Health-System Pharmacists. Archived from the original on 2015-01-05. Retrieved Jan 1, 2015.</ref><ref name="a6">PMID:20739216</ref> See also [https://en.wikipedia.org/wiki/Aciclovir Aciclovir].
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Aciclovir is converted by viral [[thymidine kinase]] to aciclovir monophosphate, which is then converted by host cell kinases to aciclovir triphosphate (ACV-TP, also known as aciclo-GTP).<ref name="a28">[https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2009-PI-00595-3 "PRODUCT INFORMATION NAME OF THE DRUG OZVIR TABLETS"] (PDF). TGA eBusiness Services. Ranbaxy Australia Pty Ltd. 26 August 2011. Archived from the original on 20 August 2016. Retrieved 6 February 2014.</ref> ACV-TP is a very potent inhibitor of viral DNA replication (see [[DNA Replication, Transcription and Translation]]. ACV-TP competitively inhibits and inactivates the viral DNA polymerase.<ref name="a41">["https://gskpro.com/content/dam/global/hcpportal/en_US/Prescribing_Information/Valtrex/pdf/VALTREX-PI-PIL.PDF VALTREX (valacyclovir hydrochloride) Caplets -GSKSource".] gsksource.com. Retrieved 2019-08-02.</ref>[41] Its monophosphate form also incorporates into the viral DNA, resulting in chain termination.<ref name="a28">[https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2009-PI-00595-3 "PRODUCT INFORMATION NAME OF THE DRUG OZVIR TABLETS"] (PDF). TGA eBusiness Services. Ranbaxy Australia Pty Ltd. 26 August 2011. Archived from the original on 20 August 2016. Retrieved 6 February 2014.</ref><ref name="a42">[https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=12ea5042-8ea6-4ee9-a734-684a73edb373] "Acyclovir (acyclovir) Capsule Acyclovir (acyclovir) Tablet [Genpharm Inc.]". DailyMed. Genpharm Inc. November 2006. Archived from the original on 21 February 2014. Retrieved 5 February 2014.</ref><ref name="a43">[https://web.archive.org/web/20140222201708/http://www.medicines.org.uk/EMC/medicine/23721/SPC/Aciclovir+Tablets+BP+400mg "Aciclovir Tablets BP 400mg - Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Actavis UK Ltd. 20 August 2012. Archived from the original on 22 February 2014. Retrieved 5 February 2014.]</ref>
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Aciclovir is converted by viral [[thymidine kinase]] to aciclovir monophosphate, which is then converted by host cell kinases to aciclovir triphosphate (ACV-TP, also known as aciclo-GTP).<ref name="a28">[https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2009-PI-00595-3 "PRODUCT INFORMATION NAME OF THE DRUG OZVIR TABLETS"] (PDF). TGA eBusiness Services. Ranbaxy Australia Pty Ltd. 26 August 2011. Archived from the original on 20 August 2016. Retrieved 6 February 2014.</ref> ACV-TP is a very potent inhibitor of viral DNA replication (see [[DNA Replication, Transcription and Translation]]). ACV-TP competitively inhibits and inactivates the viral [[DNA polymerase]].<ref name="a41">["https://gskpro.com/content/dam/global/hcpportal/en_US/Prescribing_Information/Valtrex/pdf/VALTREX-PI-PIL.PDF VALTREX (valacyclovir hydrochloride) Caplets -GSKSource".] gsksource.com. Retrieved 2019-08-02.</ref>[41] Its monophosphate form also incorporates into the viral DNA, resulting in chain termination.<ref name="a28">[https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2009-PI-00595-3 "PRODUCT INFORMATION NAME OF THE DRUG OZVIR TABLETS"] (PDF). TGA eBusiness Services. Ranbaxy Australia Pty Ltd. 26 August 2011. Archived from the original on 20 August 2016. Retrieved 6 February 2014.</ref><ref name="a42">[https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=12ea5042-8ea6-4ee9-a734-684a73edb373] "Acyclovir (acyclovir) Capsule Acyclovir (acyclovir) Tablet [Genpharm Inc.]". DailyMed. Genpharm Inc. November 2006. Archived from the original on 21 February 2014. Retrieved 5 February 2014.</ref><ref name="a43">[https://web.archive.org/web/20140222201708/http://www.medicines.org.uk/EMC/medicine/23721/SPC/Aciclovir+Tablets+BP+400mg "Aciclovir Tablets BP 400mg - Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Actavis UK Ltd. 20 August 2012. Archived from the original on 22 February 2014. Retrieved 5 February 2014.]</ref>
[[2ki5]].
[[2ki5]].

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References

  1. ↑ Kevin ES. "The Aciclovir" (in German). Kevin. Retrieved 25 May 2017.
  2. ↑ de Clercq E, Field HJ (5 October 2005). "Antiviral prodrugs – the development of successful prodrug strategies for antiviral chemotherapy". British Journal of Pharmacology. Vol. 147, no. 1. Wiley-Blackwell (published January 2006). pp. 1–11.
  3. ↑ 3.0 3.1 "Acyclovir". The American Society of Health-System Pharmacists. Archived from the original on 2015-01-05. Retrieved Jan 1, 2015.
  4. ↑ Rafailidis PI, Mavros MN, Kapaskelis A, Falagas ME. Antiviral treatment for severe EBV infections in apparently immunocompetent patients. J Clin Virol. 2010 Nov;49(3):151-7. PMID:20739216 doi:10.1016/j.jcv.2010.07.008
  5. ↑ 5.0 5.1 "PRODUCT INFORMATION NAME OF THE DRUG OZVIR TABLETS" (PDF). TGA eBusiness Services. Ranbaxy Australia Pty Ltd. 26 August 2011. Archived from the original on 20 August 2016. Retrieved 6 February 2014.
  6. ↑ ["https://gskpro.com/content/dam/global/hcpportal/en_US/Prescribing_Information/Valtrex/pdf/VALTREX-PI-PIL.PDF VALTREX (valacyclovir hydrochloride) Caplets -GSKSource".] gsksource.com. Retrieved 2019-08-02.
  7. ↑ [1] "Acyclovir (acyclovir) Capsule Acyclovir (acyclovir) Tablet [Genpharm Inc.]". DailyMed. Genpharm Inc. November 2006. Archived from the original on 21 February 2014. Retrieved 5 February 2014.
  8. ↑ "Aciclovir Tablets BP 400mg - Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Actavis UK Ltd. 20 August 2012. Archived from the original on 22 February 2014. Retrieved 5 February 2014.

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