7yc2
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of auxiliary protein in complex with human protein== | |
| - | + | <StructureSection load='7yc2' size='340' side='right'caption='[[7yc2]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7yc2]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YC2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YC2 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yc2 OCA], [https://pdbe.org/7yc2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yc2 RCSB], [https://www.ebi.ac.uk/pdbsum/7yc2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yc2 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Cui | + | == Function == |
| + | [https://www.uniprot.org/uniprot/ZY11B_HUMAN ZY11B_HUMAN] Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts redudantly with ZER1 to target substrates bearing N-terminal glycine degrons for proteasomal degradation (PubMed:33093214). Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylation (PubMed:31273098).<ref>PMID:31273098</ref> <ref>PMID:33093214</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Severe acute respiratory syndrome coronavirus 2]] | ||
| + | [[Category: Cui S]] | ||
| + | [[Category: Gao X]] | ||
Revision as of 07:59, 6 December 2023
Crystal structure of auxiliary protein in complex with human protein
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