8cp6
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Type six secretion system exported effector 5 (Tse5)== | |
| + | <StructureSection load='8cp6' size='340' side='right'caption='[[8cp6]], [[Resolution|resolution]] 2.45Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8cp6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CP6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CP6 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.45Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cp6 OCA], [https://pdbe.org/8cp6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cp6 RCSB], [https://www.ebi.ac.uk/pdbsum/8cp6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cp6 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TSE5_PSEAE TSE5_PSEAE] Toxin secreted by the H1 type VI (H1-T6SS) secretion system that acts on bacterial target cells. The producing bacterium is protected by a cognate immunity protein.<ref>PMID:24589350</ref> <ref>PMID:24794869</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Bacterial competition is a significant driver of toxin polymorphism, which allows continual compensatory evolution between toxins and the resistance developed to overcome their activity. Bacterial Rearrangement hot spot (Rhs) proteins represent a widespread example of toxin polymorphism. Here, we present the 2.45 A cryo-electron microscopy structure of Tse5, an Rhs protein central to Pseudomonas aeruginosa type VI secretion system-mediated bacterial competition. This structural insight, coupled with an extensive array of biophysical and genetic investigations, unravels the multifaceted functional mechanisms of Tse5. The data suggest that interfacial Tse5-membrane binding delivers its encapsulated pore-forming toxin fragment to the target bacterial membrane, where it assembles pores that cause cell depolarisation and, ultimately, bacterial death. | ||
| - | + | Structural and functional insights into the delivery of a bacterial Rhs pore-forming toxin to the membrane.,Gonzalez-Magana A, Tascon I, Altuna-Alvarez J, Queralt-Martin M, Colautti J, Velazquez C, Zabala M, Rojas-Palomino J, Cardenas M, Alcaraz A, Whitney JC, Ubarretxena-Belandia I, Albesa-Jove D Nat Commun. 2023 Nov 28;14(1):7808. doi: 10.1038/s41467-023-43585-5. PMID:38016939<ref>PMID:38016939</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 8cp6" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Pseudomonas aeruginosa]] | ||
| + | [[Category: Albesa-Jove D]] | ||
| + | [[Category: Gonzalez-Magana A]] | ||
| + | [[Category: Tascon I]] | ||
| + | [[Category: Ubarretxena-Belandia I]] | ||
Current revision
Type six secretion system exported effector 5 (Tse5)
| |||||||||||
