8v15
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Human SIRT3 bound to p53-AMC peptide, Carba-NAD, and Honokiol== | |
| - | + | <StructureSection load='8v15' size='340' side='right'caption='[[8v15]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8v15]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8V15 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8V15 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CNA:CARBA-NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>CNA</scene>, <scene name='pdbligand=FDL:N~6~-ACETYL-N-(4-METHYL-2-OXO-2H-CHROMEN-7-YL)-L-LYSINAMIDE'>FDL</scene>, <scene name='pdbligand=Y4T:(1P)-3,5-di(prop-2-en-1-yl)[1,1-biphenyl]-2,4-diol'>Y4T</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8v15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8v15 OCA], [https://pdbe.org/8v15 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8v15 RCSB], [https://www.ebi.ac.uk/pdbsum/8v15 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8v15 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/SIR3_HUMAN SIR3_HUMAN] NAD-dependent protein deacetylase. Activates mitochondrial target proteins, including ACSS1, IDH2 and GDH by deacetylating key lysine residues. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.<ref>PMID:16788062</ref> <ref>PMID:18680753</ref> <ref>PMID:18794531</ref> <ref>PMID:19535340</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: Guan | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Roy | + | [[Category: Chakrabarti R]] |
| - | [[Category: | + | [[Category: Chall S]] |
| + | [[Category: Delacroix T]] | ||
| + | [[Category: Dumpati RK]] | ||
| + | [[Category: Errasti G]] | ||
| + | [[Category: Ghosh A]] | ||
| + | [[Category: Guan X]] | ||
| + | [[Category: Munshi S]] | ||
| + | [[Category: Rahnamoun A]] | ||
| + | [[Category: Reverdy C]] | ||
| + | [[Category: Roy S]] | ||
| + | [[Category: Upadhyay A]] | ||
Current revision
Human SIRT3 bound to p53-AMC peptide, Carba-NAD, and Honokiol
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Categories: Homo sapiens | Large Structures | Chakrabarti R | Chall S | Delacroix T | Dumpati RK | Errasti G | Ghosh A | Guan X | Munshi S | Rahnamoun A | Reverdy C | Roy S | Upadhyay A
