8wb0

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'''Unreleased structure'''
 
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The entry 8wb0 is ON HOLD until Paper Publication
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==De novo transcribing complex 17 (TC17), the early elongation complex with Pol II positioned 17nt downstream of TSS==
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<StructureSection load='8wb0' size='340' side='right'caption='[[8wb0]], [[Resolution|resolution]] 2.94&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8wb0]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Amanita_phalloides Amanita phalloides], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WB0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WB0 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.94&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene>, <scene name='pdbligand=G2L:3-O-METHYOXYETHYL-GUANOSINE-5-MONOPHOSPHATE'>G2L</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=ILX:4,5-DIHYDROXYISOLEUCINE'>ILX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PRD_000201:Alpha-Amanitin'>PRD_000201</scene>, <scene name='pdbligand=TRX:6-HYDROXYTRYPTOPHAN'>TRX</scene>, <scene name='pdbligand=W0F:[[(2~{S},3~{R},4~{S},5~{R})-5-(2-azanyl-6-oxidanylidene-3~{H}-purin-9-yl)-3-methoxy-4-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]+phosphono+hydrogen+phosphate'>W0F</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wb0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wb0 OCA], [https://pdbe.org/8wb0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wb0 RCSB], [https://www.ebi.ac.uk/pdbsum/8wb0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wb0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AAMAT_AMAPH AAMAT_AMAPH] Major toxin belonging to the bicyclic octapeptides amatoxins that acts by binding non-competitively to RNA polymerase II and greatly slowing the elongation of transcripts from target promoters (PubMed:4865716, PubMed:363352, PubMed:7642577, PubMed:8702941).<ref>PMID:363352</ref> <ref>PMID:4865716</ref> <ref>PMID:7642577</ref> <ref>PMID:8702941</ref> <ref>PMID:24613547</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Amanita phalloides]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Sus scrofa]]
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[[Category: Synthetic construct]]
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[[Category: Chen X]]
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[[Category: Li W]]
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[[Category: Liu W]]
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[[Category: Qu X]]
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[[Category: Ren Y]]
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[[Category: Wang Q]]
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[[Category: Wang X]]
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[[Category: Xu Y]]

Revision as of 08:07, 6 December 2023

De novo transcribing complex 17 (TC17), the early elongation complex with Pol II positioned 17nt downstream of TSS

PDB ID 8wb0

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OCA

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