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8wx2

From Proteopedia

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m (Protected "8wx2" [edit=sysop:move=sysop])
Current revision (08:08, 6 December 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8wx2 is ON HOLD
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==Cryo-EM structure of human SLC15A3 (outward-facing partially occluded)==
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<StructureSection load='8wx2' size='340' side='right'caption='[[8wx2]], [[Resolution|resolution]] 3.44&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8wx2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WX2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WX2 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.44&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wx2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wx2 OCA], [https://pdbe.org/8wx2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wx2 RCSB], [https://www.ebi.ac.uk/pdbsum/8wx2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wx2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/S15A3_HUMAN S15A3_HUMAN] Proton-coupled amino-acid transporter that transports free histidine and certain di- and tripeptides, and is involved in innate immune response (By similarity). Also able to transport carnosine (PubMed:31073693, PubMed:31254495). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (By similarity).[UniProtKB:Q8BPX9]<ref>PMID:31073693</ref> <ref>PMID:31254495</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Kasai S]]
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[[Category: Ohto U]]
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[[Category: Shimizu T]]
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[[Category: Zhang Z]]

Current revision

Cryo-EM structure of human SLC15A3 (outward-facing partially occluded)

PDB ID 8wx2

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OCA

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